Cerebellar granulocytic sarcoma in an infant with CD56+ acute monoblastic leukemia

Granulocytic sarcoma (GS) is a form of extramedullary leukaemia (EML). The presence of the neural cell adhesion molecule (NCAM) on the surface of the blasts, which is recognized by the CD56 monoclonal antibody, enhances their propensity for tissue penetration. GS within the central nervous system (C...

Full description

Saved in:
Bibliographic Details
Published in:Leukemia research 2001-11, Vol.25 (11), p.1019-1021
Main Authors: Psiachou-Leonard, Elene, Paterakis, Georgios, Stefanaki, Kalliopi, Mikraki-Christou, Vasiliki, Haidas, Stavros
Format: Article
Language:English
Subjects:
Acute myeloid leukaemia
Biological and medical sciences
CD56 Antigen - analysis
Cerebellar Neoplasms - etiology
Cerebellar Neoplasms - pathology
Cerebellum
Fatal Outcome
Granulocytic sarcoma
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Infant
Leukemia, Monocytic, Acute - complications
Leukemia, Monocytic, Acute - diagnosis
Leukemia, Monocytic, Acute - immunology
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukemic Infiltration
Magnetic Resonance Imaging
Male
Medical sciences
NCAM
Sarcoma, Myeloid - etiology
Sarcoma, Myeloid - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Granulocytic sarcoma (GS) is a form of extramedullary leukaemia (EML). The presence of the neural cell adhesion molecule (NCAM) on the surface of the blasts, which is recognized by the CD56 monoclonal antibody, enhances their propensity for tissue penetration. GS within the central nervous system (CNS), in particular within the cerebellum, is extremely uncommon. We review the literature and describe an infant with isolated cerebellar GS relapse, which antedated a CD56+ acute monoblastic leukaemia bone marrow (BM) relapse.
ISSN:0145-2126
1873-5835
DOI:10.1016/S0145-2126(01)00068-6