Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors

A method is presented for the acquisition and analysis of dynamic contrast‐enhanced (DCE) MRI data, focused on the characterization of tumors in humans. Gadolinium (Gd) contrast was administered by bolus injection, and its effect was monitored in time by fast T1‐weighted MRI. A simple algorithm was...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2001-10, Vol.14 (4), p.457-463
Main Authors: Rijpkema, Mark, Kaanders, Johannes H.A.M., Joosten, Frank B.M., van der Kogel, Albert J., Heerschap, Arend
Format: Article
Language:English
Subjects:
Algorithms
arterial input function
Brain Neoplasms - metabolism
Contrast Media - pharmacokinetics
dynamic MRI
Gadolinium - pharmacokinetics
gadolinium uptake rate
Head and Neck Neoplasms - metabolism
human tumors
Humans
Magnetic Resonance Imaging
Male
Neoplasms - metabolism
Prostatic Neoplasms - metabolism
Reproducibility of Results
Tissue Distribution
tracer kinetics
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Summary:A method is presented for the acquisition and analysis of dynamic contrast‐enhanced (DCE) MRI data, focused on the characterization of tumors in humans. Gadolinium (Gd) contrast was administered by bolus injection, and its effect was monitored in time by fast T1‐weighted MRI. A simple algorithm was developed for automatic extraction of the arterial input function (AIF) from the DCE‐MRI data. This AIF was used in the pixelwise pharmacokinetic determination of physiological vascular parameters in normal and tumor tissue. Maps were reconstructed to show the spatial distribution of parameter values. To test the reproducibility of the method 11 patients with different types of tumors were measured twice, and the rate of contrast agent uptake in the tumor was calculated. The results show that normalizing the DCE‐MRI data using individual coregistered AIFs, instead of one common AIF for all patients, substantially reduces the variation between successive measurements. It is concluded that the proposed method enables the reproducible assessment of contrast agent uptake rates. J. Magn. Reson. Imaging 2001;14:457–463. © 2001 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.1207