Outbreak of Human Parainfluenza Virus 3 Infections in a Hematopoietic Stem Cell Transplant Population

Clinical manifestations and epidemiological features are described for a cluster of 12 cases of human parainfluenza virus 3 (HPIV3) infection that occurred among 64 allogeneic hematopoietic stem cell transplant (SCT) recipients in an 11-week period during spring 2000. Upper respiratory symptoms pred...

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Bibliographic Details
Published in:The Journal of infectious diseases 2001-11, Vol.184 (9), p.1093-1097
Main Authors: Cortez, Karoll J., Erdman, Dean D., Peret, Teresa C. T., Gill, Vee J., Childs, Richard, Barrett, A. John, Bennett, John E.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Bone marrow
Disease Outbreaks
Disease transmission
Family members
Hematopoietic Stem Cell Transplantation - adverse effects
HN Protein - genetics
Human parainfluenza virus 3
Human viral diseases
Humans
Infections
Infectious diseases
Major Articles
Medical sciences
Parainfluenza Virus 3, Human - classification
Parainfluenza Virus 3, Human - genetics
Parainfluenza Virus 3, Human - isolation & purification
Paramyxoviridae infections
Pharmacology. Drug treatments
Respiratory symptoms
Respirovirus Infections - epidemiology
Respirovirus Infections - virology
Reverse Transcriptase Polymerase Chain Reaction
Sequence Analysis, DNA
Symptoms
Transplantation
Transplantation, Homologous
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral infections
Viruses
Citations: Items that cite this one
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Description
Summary:Clinical manifestations and epidemiological features are described for a cluster of 12 cases of human parainfluenza virus 3 (HPIV3) infection that occurred among 64 allogeneic hematopoietic stem cell transplant (SCT) recipients in an 11-week period during spring 2000. Upper respiratory symptoms predominated. Pneumonia occurred in 3 patients and was a contributing factor in the death of 1 patient. Exposure histories and molecular analysis of HPIV3 isolates suggested that both community acquired and nosocomially transmitted infections occurred during this outbreak. A chain of transmission within the outpatient clinic appeared to have occurred in 4 outpatients and to have extended to 2 hospitalized patients. Molecular epidemiology was useful in discerning routes of transmission in this outbreak
ISSN:0022-1899
1537-6613
DOI:10.1086/322041