Macrophages, neutrophils and tumour necrosis factor- α expression in bronchiectatic airways in vivo

Bronchiectasis is increasingly being recognized as an inflammatory condition of the airways in which pathological permanent dilation occurs. We have obtained endobronchial biopsies in 14 patients with stable bronchiectasis and 15 control subjects. Airway neutrophils, macrophages and tumour necrosis...

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Bibliographic Details
Published in:Respiratory medicine 2001-10, Vol.95 (10), p.792-798
Main Authors: ZHENG, L., SHUM, I.H., TIPOE, G.L., LEUNG, R., LAM, W.K., OOI, G.C., TSANG, K.W.
Format: Article
Language:English
Subjects:
Aged
airway biopsy
Antigens, CD - analysis
Antigens, Differentiation, Myelomonocytic - analysis
Biological and medical sciences
Biomarkers - analysis
bronchiectasis
Bronchiectasis - immunology
Bronchiectasis - pathology
Bronchoscopy
Case-Control Studies
Cell Count
Female
Humans
Immunohistochemistry
Lung - immunology
Lung - pathology
macrophages
Macrophages - metabolism
Macrophages - pathology
Male
Medical sciences
Middle Aged
neutrophils
Neutrophils - metabolism
Neutrophils - pathology
Pancreatic Elastase - analysis
Pneumology
Respiratory system : syndromes and miscellaneous diseases
Statistics, Nonparametric
Tumor Necrosis Factor-alpha - metabolism
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Summary:Bronchiectasis is increasingly being recognized as an inflammatory condition of the airways in which pathological permanent dilation occurs. We have obtained endobronchial biopsies in 14 patients with stable bronchiectasis and 15 control subjects. Airway neutrophils, macrophages and tumour necrosis factor- α (TNF α)-positive cells were stained with monoclonal antibodies and the densities of positive cells in the lamina propria were determined by using a computer image analyser. There was significantly higher neutrophil, macrophage and TNF α -positive cell densities in the lamina propria of bronchiectatic than control airways (P
ISSN:0954-6111
1532-3064
DOI:10.1053/rmed.2001.1155