Relationship between Anti-Insulin Antibodies and Albuminuria or Proteinuria in Human Insulin-Treated Type 2 Diabetes Mellitus

In order to examine the relationship between anti-insulin antibodies (ALA) caused by extrinsic human insulin and albuminuria or proteinuria, 53 human insulin-treated type 2 diabetics were divided into two groups： (AIA(+) group) 27 patients with a titer of AlA greater than 7.6% and (AIA(-) group) 26...

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Published in:ENDOCRINE JOURNAL 2001, Vol.48 (4), p.487-491
Main Author: Katahira, M
Format: Article
Language:English
Subjects:
Adult
Aged
Albuminuria - immunology
Autoantibodies - blood
Creatinine - urine
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - immunology
Female
Humans
Insulin - immunology
Insulin - therapeutic use
Male
Middle Aged
Proteinuria - immunology
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description In order to examine the relationship between anti-insulin antibodies (ALA) caused by extrinsic human insulin and albuminuria or proteinuria, 53 human insulin-treated type 2 diabetics were divided into two groups： (AIA(+) group) 27 patients with a titer of AlA greater than 7.6% and (AIA(-) group) 26 patients with a titer of ALA less than 7.5%. Although no significant difference was found between the two groups for age, gender, body mass index, duration of diabetes, duration of insulin treatment, blood pressure, serum creatinine, glycosylated hemoglobin (HbA1c), daily dose of insulin, daily insulin injection times, or treatment of hypertension, the AIA(+) group had a significantly higher urinary albumin to creatinine ratio and urinary protein to creatinine ratio than the AIA(-) group (p
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source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - English
subjects Adult
Aged
Albuminuria - immunology
Autoantibodies - blood
Creatinine - urine
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - immunology
Female
Humans
Insulin - immunology
Insulin - therapeutic use
Male
Middle Aged
Proteinuria - immunology
title Relationship between Anti-Insulin Antibodies and Albuminuria or Proteinuria in Human Insulin-Treated Type 2 Diabetes Mellitus
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