Bioanalytical utility of sonovoltammetry

Dopamine dissolved within egg homogenate was used as a model system to study the effects of electrode contamination and its subsequent reactivation through ultrasonically mediated in situ cleaning effects. The merits in conducting electroanalytical investigations under the influence of the ultrasoni...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2001-12, Vol.26 (5), p.995-1001
Main Authors: Beckett, Emma L, Lawrence, Nathan S, Tsai, Yu Chen, Davis, James, Compton, Richard G
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Dopamine
Dopamine - analysis
Eggs - analysis
Electroanalysis
Electrochemical detection
Electrochemistry - instrumentation
Electrochemistry - methods
Electrodes
General pharmacology
Medical sciences
Microscopy, Atomic Force
Pharmacology. Drug treatments
Sonoelectrochemistry
Ultrasonics
Ultrasound
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Summary:Dopamine dissolved within egg homogenate was used as a model system to study the effects of electrode contamination and its subsequent reactivation through ultrasonically mediated in situ cleaning effects. The merits in conducting electroanalytical investigations under the influence of the ultrasonic field were also appraised. Maintaining the ultrasound field during oxidative measurements was found to yield hydrodynamic profiles that were linear over the concentration range 2–20 μM dopamine. The resulting sonolinear sweep voltammograms were compared with conventional rotating disk measurements, with the former found to provide significantly increased limiting currents that were attenuable through the manipulation of the field intensity. The problem of retaining selectivity in the presence of high concentrations of ascorbate was also assessed with the addition of cupric ion prior to commencing the measurements found to efficiently negate an otherwise substantive interference.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(01)00494-0