Nucleotide sequence analysis of a novel circovirus of canaries and its relationship to other members of the genus Circovirus of the family Circoviridae

The circular, single-stranded DNA genome of a novel circovirus of canaries, tentatively named canary circovirus (CaCV), was cloned and sequenced. Sequence analysis indicated that the genome was 1952 nucleotides (nt) in size and had the potential to encode three viral proteins, including the putative...

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Bibliographic Details
Published in:Journal of general virology 2001-11, Vol.82 (11), p.2805-2809
Main Authors: Phenix, K.V, Weston, J.H, Ypelaar, I, Lavazza, A, Smyth, J.A, Todd, D, Wilcox, G.E, Raidal, S.R
Format: Article
Language:English
Subjects:
amino acid motifs
Amino Acid Sequence
Animals
Beak and feather disease virus
Bird Diseases - virology
Canaries
Canary circovirus
capsid
Circoviridae - classification
Circoviridae - genetics
Circoviridae Infections - veterinary
Circoviridae Infections - virology
Circovirus
Circovirus - classification
Circovirus - genetics
genome
Genome, Viral
Goose Circovirus
Molecular Sequence Data
nucleotide sequences
nucleotides
phylogeny
Porcine circovirus
Rep protein
Sequence Analysis, DNA
sequence homology
single-stranded DNA
viral proteins
virus replication
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Summary:The circular, single-stranded DNA genome of a novel circovirus of canaries, tentatively named canary circovirus (CaCV), was cloned and sequenced. Sequence analysis indicated that the genome was 1952 nucleotides (nt) in size and had the potential to encode three viral proteins, including the putative capsid and replication-associated (Rep) proteins. The CaCV genome shared greatest sequence similarity (58.3% nt identity) with the newly characterized columbid circovirus (CoCV) and was more distantly related to the two porcine circovirus strains, PCV1 and PCV2, beak and feather disease virus (BFDV) and a recently isolated goose circovirus (GCV) isolate (46.8-50.9% nt identity). In common with other members of the Circovirus genus, several nt structures and amino acid motifs thought to be implicated in virus replication were identified on the putative viral strand. Phylogenetic analysis of both the capsid and Rep protein-coding regions provided further evidence that CaCV is more closely related to CoCV and BFDV and more distantly related to GCV, PCV1 and PCV2.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-82-11-2805