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Altered renal function in growth-restricted newborn piglets
The effect of intrauterine growth restriction (IUGR) on renal hemodynamics and excretory functions was studied in 76 newborn piglets 12-27 h old. The experiments were performed on anesthetized animals divided into normal-weight piglets and IUGR piglets according to their birth weight. The "norm...
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| Published in: | Pediatric nephrology (Berlin, West) West), 2000-08, Vol.14 (8-9), p.735-739 |
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| container_issue | 8-9 |
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| container_title | Pediatric nephrology (Berlin, West) |
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| creator | BAUER, R WALTER, B IHRING, W KLUGE, H LAMPE, V ZWIENER, U |
| description | The effect of intrauterine growth restriction (IUGR) on renal hemodynamics and excretory functions was studied in 76 newborn piglets 12-27 h old. The experiments were performed on anesthetized animals divided into normal-weight piglets and IUGR piglets according to their birth weight. The "normal-weight" category included animals with a birth weight >40th percentile (piglets heavier than 1,220 g); the IUGR category included animals with a birth weight >5th and |
| doi_str_mv | 10.1007/PL00013427 |
| format | article |
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The experiments were performed on anesthetized animals divided into normal-weight piglets and IUGR piglets according to their birth weight. The "normal-weight" category included animals with a birth weight >40th percentile (piglets heavier than 1,220 g); the IUGR category included animals with a birth weight >5th and <10th percentiles (piglets with a birth weight between 733 g and 853 g). Cardiac output and renal blood flow were measured by the colored microsphere technique. Urine was collected from catheters placed in the ureters. This animal model of naturally occurring growth retardation in swine gives asymmetric growth with an increase in the mean ratio of brain weight to liver weight from 1.02 to 1.85 (P<0.01). Thus there was only a small reduction in brain weight (11%). In contrast, the reduction in the weight of liver (50%) and kidney (46%) was proportional to that in body weight (46%). Heart rate, cardiac output, arterial blood gases, and pH were similar in normal-weight and IUGR piglets, but arterial blood pressure and arterial glucose content were significantly reduced in IUGR piglets (P<0.01). Moreover, IUGR piglets had higher plasma catecholamine levels (P<0.05). Renal blood flow and renal vascular resistance were similar in the normal-weight and in the IUGR groups. However, in IUGR animals, glomerular filtration rate was significantly less than in the controls (P<0.05). Normal-weight and IUGR newborn piglets reabsorbed sodium very efficiently, the fractional sodium excretion was less than 1% in both groups. We conclude that renal blood flow is maintained in relation to kidney and body weight in IUGR newborns, but that important renal excretory functions are compromised due to IUGR.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/PL00013427</identifier><identifier>PMID: 10955917</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Animals, Newborn ; Biological and medical sciences ; Birth Weight ; Blood pressure ; Brain - anatomy & histology ; Carbon Dioxide - blood ; Cardiac Output ; Catheters ; Diseases of mother, fetus and pregnancy ; Embryonic and Fetal Development ; Female ; Fetal Growth Retardation - embryology ; Fetal Growth Retardation - physiopathology ; Gynecology. Andrology. Obstetrics ; Heart rate ; Hemodynamics ; Hemodynamics - physiology ; Hogs ; Hypertension ; Kidney - anatomy & histology ; Kidney - physiology ; Kidney - physiopathology ; Liver ; Liver - anatomy & histology ; Medical sciences ; Nitrous oxide ; Organ Size ; Oxygen - blood ; Partial Pressure ; Pregnancy ; Pregnancy. Fetus. Placenta ; Reference Values ; Regional Blood Flow ; Renal Circulation - physiology ; Swine ; Urine</subject><ispartof>Pediatric nephrology (Berlin, West), 2000-08, Vol.14 (8-9), p.735-739</ispartof><rights>2000 INIST-CNRS</rights><rights>IPNA - International Pediatric Nephrology Association New York, USA 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-a19f7fcfb392115f8e309bcd97c65e014e178dfbafe8c53600eabc38ce36e52d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1443901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10955917$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BAUER, R</creatorcontrib><creatorcontrib>WALTER, B</creatorcontrib><creatorcontrib>IHRING, W</creatorcontrib><creatorcontrib>KLUGE, H</creatorcontrib><creatorcontrib>LAMPE, V</creatorcontrib><creatorcontrib>ZWIENER, U</creatorcontrib><title>Altered renal function in growth-restricted newborn piglets</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>The effect of intrauterine growth restriction (IUGR) on renal hemodynamics and excretory functions was studied in 76 newborn piglets 12-27 h old. The experiments were performed on anesthetized animals divided into normal-weight piglets and IUGR piglets according to their birth weight. The "normal-weight" category included animals with a birth weight >40th percentile (piglets heavier than 1,220 g); the IUGR category included animals with a birth weight >5th and <10th percentiles (piglets with a birth weight between 733 g and 853 g). Cardiac output and renal blood flow were measured by the colored microsphere technique. Urine was collected from catheters placed in the ureters. This animal model of naturally occurring growth retardation in swine gives asymmetric growth with an increase in the mean ratio of brain weight to liver weight from 1.02 to 1.85 (P<0.01). Thus there was only a small reduction in brain weight (11%). In contrast, the reduction in the weight of liver (50%) and kidney (46%) was proportional to that in body weight (46%). Heart rate, cardiac output, arterial blood gases, and pH were similar in normal-weight and IUGR piglets, but arterial blood pressure and arterial glucose content were significantly reduced in IUGR piglets (P<0.01). Moreover, IUGR piglets had higher plasma catecholamine levels (P<0.05). Renal blood flow and renal vascular resistance were similar in the normal-weight and in the IUGR groups. However, in IUGR animals, glomerular filtration rate was significantly less than in the controls (P<0.05). Normal-weight and IUGR newborn piglets reabsorbed sodium very efficiently, the fractional sodium excretion was less than 1% in both groups. We conclude that renal blood flow is maintained in relation to kidney and body weight in IUGR newborns, but that important renal excretory functions are compromised due to IUGR.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Blood pressure</subject><subject>Brain - anatomy & histology</subject><subject>Carbon Dioxide - blood</subject><subject>Cardiac Output</subject><subject>Catheters</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Embryonic and Fetal Development</subject><subject>Female</subject><subject>Fetal Growth Retardation - embryology</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>Hemodynamics - physiology</subject><subject>Hogs</subject><subject>Hypertension</subject><subject>Kidney - anatomy & histology</subject><subject>Kidney - physiology</subject><subject>Kidney - physiopathology</subject><subject>Liver</subject><subject>Liver - anatomy & histology</subject><subject>Medical sciences</subject><subject>Nitrous oxide</subject><subject>Organ Size</subject><subject>Oxygen - blood</subject><subject>Partial Pressure</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Reference Values</subject><subject>Regional Blood Flow</subject><subject>Renal Circulation - physiology</subject><subject>Swine</subject><subject>Urine</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNpd0E1LAzEQBuAgiq0fF3-ALCIehNVMstskeCrFLyjoQaG3JZud1C3bbE12Kf57U1qoOJe5PLzMvIRcAL0DSsX9-5RSCjxj4oAMIeMsBSVnh2RIFYeUZjAbkJMQFlHJXI6OyQCoynMFYkgexk2HHqvEo9NNYntnurp1Se2SuW_X3VfqMXS-Nl00Dtdl612yqucNduGMHFndBDzf7VPy-fT4MXlJp2_Pr5PxNDWcqy7VoKywxpZcMYDcSuRUlaZSwoxypJAhCFnZUluUJucjSlGXhkuDfIQ5q_gpudnmrnz73cdzimUdDDaNdtj2oRCMUcqBRXj1Dy7a3se_QsHiSBBqg263yPg2BI-2WPl6qf1PAbTY9Fns-4z4cpfYl0us_tBtgRFc74AORjfWa2fqsHdZxlXM-gUuL3ww</recordid><startdate>20000801</startdate><enddate>20000801</enddate><creator>BAUER, R</creator><creator>WALTER, B</creator><creator>IHRING, W</creator><creator>KLUGE, H</creator><creator>LAMPE, V</creator><creator>ZWIENER, U</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20000801</creationdate><title>Altered renal function in growth-restricted newborn piglets</title><author>BAUER, R ; WALTER, B ; IHRING, W ; KLUGE, H ; LAMPE, V ; ZWIENER, U</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-a19f7fcfb392115f8e309bcd97c65e014e178dfbafe8c53600eabc38ce36e52d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Blood pressure</topic><topic>Brain - anatomy & histology</topic><topic>Carbon Dioxide - blood</topic><topic>Cardiac Output</topic><topic>Catheters</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Embryonic and Fetal Development</topic><topic>Female</topic><topic>Fetal Growth Retardation - embryology</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Hemodynamics - physiology</topic><topic>Hogs</topic><topic>Hypertension</topic><topic>Kidney - anatomy & histology</topic><topic>Kidney - physiology</topic><topic>Kidney - physiopathology</topic><topic>Liver</topic><topic>Liver - anatomy & histology</topic><topic>Medical sciences</topic><topic>Nitrous oxide</topic><topic>Organ Size</topic><topic>Oxygen - blood</topic><topic>Partial Pressure</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Reference Values</topic><topic>Regional Blood Flow</topic><topic>Renal Circulation - physiology</topic><topic>Swine</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BAUER, R</creatorcontrib><creatorcontrib>WALTER, B</creatorcontrib><creatorcontrib>IHRING, W</creatorcontrib><creatorcontrib>KLUGE, H</creatorcontrib><creatorcontrib>LAMPE, V</creatorcontrib><creatorcontrib>ZWIENER, U</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health & Medical Collection (ProQuest Medical & Health Databases)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric nephrology (Berlin, West)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BAUER, R</au><au>WALTER, B</au><au>IHRING, W</au><au>KLUGE, H</au><au>LAMPE, V</au><au>ZWIENER, U</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Altered renal function in growth-restricted newborn piglets</atitle><jtitle>Pediatric nephrology (Berlin, West)</jtitle><addtitle>Pediatr Nephrol</addtitle><date>2000-08-01</date><risdate>2000</risdate><volume>14</volume><issue>8-9</issue><spage>735</spage><epage>739</epage><pages>735-739</pages><issn>0931-041X</issn><eissn>1432-198X</eissn><coden>PENED3</coden><abstract>The effect of intrauterine growth restriction (IUGR) on renal hemodynamics and excretory functions was studied in 76 newborn piglets 12-27 h old. The experiments were performed on anesthetized animals divided into normal-weight piglets and IUGR piglets according to their birth weight. The "normal-weight" category included animals with a birth weight >40th percentile (piglets heavier than 1,220 g); the IUGR category included animals with a birth weight >5th and <10th percentiles (piglets with a birth weight between 733 g and 853 g). Cardiac output and renal blood flow were measured by the colored microsphere technique. Urine was collected from catheters placed in the ureters. This animal model of naturally occurring growth retardation in swine gives asymmetric growth with an increase in the mean ratio of brain weight to liver weight from 1.02 to 1.85 (P<0.01). Thus there was only a small reduction in brain weight (11%). In contrast, the reduction in the weight of liver (50%) and kidney (46%) was proportional to that in body weight (46%). Heart rate, cardiac output, arterial blood gases, and pH were similar in normal-weight and IUGR piglets, but arterial blood pressure and arterial glucose content were significantly reduced in IUGR piglets (P<0.01). Moreover, IUGR piglets had higher plasma catecholamine levels (P<0.05). Renal blood flow and renal vascular resistance were similar in the normal-weight and in the IUGR groups. However, in IUGR animals, glomerular filtration rate was significantly less than in the controls (P<0.05). Normal-weight and IUGR newborn piglets reabsorbed sodium very efficiently, the fractional sodium excretion was less than 1% in both groups. We conclude that renal blood flow is maintained in relation to kidney and body weight in IUGR newborns, but that important renal excretory functions are compromised due to IUGR.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>10955917</pmid><doi>10.1007/PL00013427</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0931-041X |
| ispartof | Pediatric nephrology (Berlin, West), 2000-08, Vol.14 (8-9), p.735-739 |
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| source | Springer Nature |
| subjects | Animals Animals, Newborn Biological and medical sciences Birth Weight Blood pressure Brain - anatomy & histology Carbon Dioxide - blood Cardiac Output Catheters Diseases of mother, fetus and pregnancy Embryonic and Fetal Development Female Fetal Growth Retardation - embryology Fetal Growth Retardation - physiopathology Gynecology. Andrology. Obstetrics Heart rate Hemodynamics Hemodynamics - physiology Hogs Hypertension Kidney - anatomy & histology Kidney - physiology Kidney - physiopathology Liver Liver - anatomy & histology Medical sciences Nitrous oxide Organ Size Oxygen - blood Partial Pressure Pregnancy Pregnancy. Fetus. Placenta Reference Values Regional Blood Flow Renal Circulation - physiology Swine Urine |
| title | Altered renal function in growth-restricted newborn piglets |
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