Primary biliary cirrhosis associated with idiopathic retroperitoneal fibrosis

Idiopathic retroperitoneal fibrosis (IRF) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report a 79-year-old man with the coexistence of both conditions. The patient had antibodies to both centromere and mitochondria, as indicated by i...

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Bibliographic Details
Published in:Journal of gastroenterology 2000, Vol.35 (8), p.646-648
Main Authors: Shikuwa, S, Omagari, K, Mizuta, Y, Murase, K, Osabe, M, Yoshimura, M, Ohfukuji, M, Takehara, Y, Isomoto, H, Ito, M, Shimokawa, I, Kohno, S
Format: Article
Language:English
Subjects:
Aged
Antibodies, Antineutrophil Cytoplasmic
Antibodies, Antinuclear - blood
Autoantibodies - blood
Centromere - immunology
Fluorescent Antibody Technique, Indirect
Humans
Liver Cirrhosis, Biliary - complications
Liver Cirrhosis, Biliary - diagnosis
Liver Cirrhosis, Biliary - immunology
Liver Cirrhosis, Biliary - pathology
Magnetic Resonance Imaging
Male
Mitochondria - immunology
Retroperitoneal Fibrosis - complications
Retroperitoneal Fibrosis - diagnosis
Retroperitoneal Fibrosis - immunology
Retroperitoneal Fibrosis - pathology
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Summary:Idiopathic retroperitoneal fibrosis (IRF) and primary biliary cirrhosis (PBC) are distinct clinical disorders which rarely occur in the same patient. We report a 79-year-old man with the coexistence of both conditions. The patient had antibodies to both centromere and mitochondria, as indicated by indirect immunofluorescence. Diagnoses of IRF and PBC were confirmed histologically. Although the association between IRF and PBC is obscure, IRF may be involved in many autoimmune diseases associated with PBC.
ISSN:0944-1174
1435-5922
DOI:10.1007/s005350070067