Effect of plasma insulin level on myocardial blood flow and its mechanism of action

Considerable evidence suggests that coronary endothelium regulates myocardial blood flow and metabolism by elaborating vasoactive substances. The physiologic signals mediating this process are uncertain. To test the hypothesis that the process is influenced by physiologic variation in local insulin...

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Bibliographic Details
Published in:The American journal of cardiology 2000-01, Vol.85 (2), p.161-165
Main Authors: McNulty, Patrick H, Pfau, Steven, Deckelbaum, Lawrence I
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular disease
Coronary Angiography
Coronary Circulation
Coronary heart disease
Heart
Hemodynamics
Humans
Insulin
Insulin - metabolism
Male
Medical sciences
Metabolism
Middle Aged
Myocardium - metabolism
Oxygen Consumption
Regional Blood Flow
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Summary:Considerable evidence suggests that coronary endothelium regulates myocardial blood flow and metabolism by elaborating vasoactive substances. The physiologic signals mediating this process are uncertain. To test the hypothesis that the process is influenced by physiologic variation in local insulin concentration, we examined the effect of direct intracoronary insulin infusion on myocardial blood flow and oxidative substrate metabolism in 10 patients with coronary heart disease. Ten men (aged 51 to 68 years) who were fasting received a 60-minute intracoronary infusion of insulin at a rate (10 mU/min) sufficient to raise coronary venous plasma insulin from 12 ± 4 to 133 ± 17 mU/ml without increasing the systemic insulin level. Local coronary hyperinsulinemia increased coronary sinus blood flow in every subject, from 50 ± 4 to 61 ± 6 ml/min (p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(99)00650-5