Effects of time of day, gender, and menstrual cycle phase on the human response to a water load

Department of Clinical Investigation, Tripler Army Medical Center, Tripler Army Medical Center, Hawaii 96859 - 5000 Estrogen and progesterone interference with renal actions of arginine vasopressin (AVP) has been shown. Thus we hypothesized that women will have a higher water turnover than men and t...

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Published in:American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2000-09, Vol.279 (3), p.966-R973
Main Authors: Claybaugh, John R, Sato, Aileen K, Crosswhite, Linda K, Hassell, L. Harrison
Format: Article
Language:English
Subjects:
Adult
Circadian Rhythm - physiology
Creatinine - metabolism
Diuresis - physiology
Drinking - physiology
Estrogens - physiology
Female
Follicular Phase - physiology
Glomerular Filtration Rate
Humans
Luteal Phase - physiology
Male
Osmolar Concentration
Potassium - urine
Progesterone - physiology
Sex Factors
Sodium - urine
Urine
Vasopressins - physiology
Water-Electrolyte Balance - physiology
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Summary:Department of Clinical Investigation, Tripler Army Medical Center, Tripler Army Medical Center, Hawaii 96859 - 5000 Estrogen and progesterone interference with renal actions of arginine vasopressin (AVP) has been shown. Thus we hypothesized that women will have a higher water turnover than men and that the greatest difference will be during the luteal phase of the menstrual cycle. Seven men (32 ± 3 yr) and six women (33 ± 2 yr) drank 12 ml water/kg lean body mass on different days at 0800   and at 2000 following 10 h of fast and a standardized meal at 0600 and 1800. Women participated on days 4-11 and 19-25 of the menstrual cycle. Initial urine and plasma osmolalities and urine flow rates were similar in all experiments. The cumulative urine voided over 3 h following the morning drink was less in men (73   ± 12% of the water load) compared with women in either the follicular (100 ± 3%) or luteal phases (102 ± 10%) of the menstrual cycle. Nighttime values (30-43% of the water load) were lower in all experiments and were not different between sexes or menstrual cycle phases. Plasma AVP was higher at night and may contribute to this diurnal response. The data are generally consistent with the stated hypothesis; however, possibly owing to the greatly reduced urine flow in both sexes at night, a difference between sexes was not observed at that time. circadian rhythm; vasopressin; urine flow; urine osmolality; plasma osmolality
ISSN:0363-6119
1522-1490
DOI:10.1152/ajpregu.2000.279.3.R966