Comparison of ropivacaine 0.1%-fentanyl and bupivacaine 0.125% -fentanyl infusions for epidural labour analgesia

To compare analgesic efficacies of ropivacaine-fentanyl and bupivacaine-fentanyl infusions for labour epidural analgesia. In this double- blind, randomized study 100, term, nulliparous women were enrolled. Lumbar epidural analgesia (LEA) was started at cervical dilatation < 5 cm using either bupi...

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Bibliographic Details
Published in:Canadian journal of anesthesia 2000-08, Vol.47 (8), p.740-745
Main Authors: FINEGOLD, H, MANDELL, G, RAMANATHAN, S
Format: Article
Language:English
Subjects:
Adult
Amides - administration & dosage
Amides - pharmacokinetics
Analgesia, Epidural
Analgesia, Obstetrical
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Bupivacaine - administration & dosage
Bupivacaine - pharmacokinetics
Double-Blind Method
Female
Fentanyl - administration & dosage
Fentanyl - pharmacokinetics
Heart Rate, Fetal - drug effects
Humans
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Pregnancy
Systole - drug effects
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Summary:To compare analgesic efficacies of ropivacaine-fentanyl and bupivacaine-fentanyl infusions for labour epidural analgesia. In this double- blind, randomized study 100, term, nulliparous women were enrolled. Lumbar epidural analgesia (LEA) was started at cervical dilatation < 5 cm using either bupivacaine 0.25% followed by bupivacaine 0.125% + 2 microg x ml(-1) fentanyl infusion (n=50) or ropivacaine 0.2% followed by ropivacaine 0.1% + 2 microg x ml(-1) fentanyl infusion (n=50). Every hour maternal vital signs, visual analog scale (VAS) pain score, sensory levels, and motor block (Bromage score) were assessed. Data were expressed as mean +/-1 SD and analyzed using Chi -Squared and Mann-Whitney U tests at
ISSN:0832-610X
1496-8975
DOI:10.1007/BF03019475