Cholinergic modulation of inhibitory avoidance impairment induced by paradoxical sleep deprivation

1. Male Wistar rats were submitted to paradoxical sleep deprivation for 96 hr by a modified multiple platform technique. 2. Training of step-through inhibitory avoidance was performed immediately after the last day of paradoxical sleep deprivation. Twenty-four hr after training the animals were subm...

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Bibliographic Details
Published in:Progress in neuro-psychopharmacology & biological psychiatry 2000-05, Vol.24 (4), p.595-606
Main Authors: BUENO, O. F. A, OLIVEIRA, M. G. M, LOBO, L. L, MORAIS, P. R, MELO, F. H. M, TUFIK, S
Format: Article
Language:English
Subjects:
Animals
Atropine - administration & dosage
Atropine - pharmacology
Avoidance Learning
Biological and medical sciences
Cholinergic system
Male
Medical sciences
Muscarinic Agonists - administration & dosage
Muscarinic Agonists - pharmacology
Muscarinic Antagonists - administration & dosage
Muscarinic Antagonists - pharmacology
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
pilocarpine
Pilocarpine - administration & dosage
Pilocarpine - pharmacology
Rats
Rats, Wistar
Receptors, Cholinergic - physiology
Sleep Deprivation
Sleep, REM - physiology
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Summary:1. Male Wistar rats were submitted to paradoxical sleep deprivation for 96 hr by a modified multiple platform technique. 2. Training of step-through inhibitory avoidance was performed immediately after the last day of paradoxical sleep deprivation. Twenty-four hr after training the animals were submitted to the retention test. 3. In Experiment 1, pilocarpine (4 mg/kg, i.p.) or atropine (4 mg/kg, i.p.) were administered daily during the paradoxical sleep deprivation period. Pilocarpine, but not atropine, reversed the impairment induced by PS deprivation. 4. In Experiment 2, pilocarpine (4, 8 and 12 mg/kg, i.p.) was injected 1 hr before training in order to verify if the reversal of memory impairment was an effect secondary to residual enhanced blood levels of pilocarpine during training. Acute treatment with pilocarpine, in any dose, did not reverse the impairment produced by paradoxical sleep deprivation 5. Activation of the cholinergic system during the period of deprivation is able to prevent memory deficits induced by paradoxical sleep deprivation.
ISSN:0278-5846
1878-4216
DOI:10.1016/S0278-5846(00)00095-6