Major histocompatibility complex (MHC)- linked microsatellite markers in a founder population

The Finnish population is genetically relatively homogeneous and has a narrow gene pool as a result of founder effect followed by rapid population growth. We here demonstrate that microsatellite markers are highly informative tools for major histocompatibility complex (MHC) analysis in this populati...

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Bibliographic Details
Published in:Tissue antigens 2000-07, Vol.56 (1), p.45-51
Main Authors: Karell, K., Klinger, N., Holopainen, P., Levo, A., Partanen, J.
Format: Article
Language:English
Subjects:
Bone Marrow Transplantation
CYP21 deficiency
Finland
Founder Effect
Genetic Linkage
genetic polymorphism
haplotype
Haplotypes
histocompatibility antigen HLA
Histocompatibility Testing
HLA
HLA Antigens - genetics
Humans
Linkage Disequilibrium
Major Histocompatibility Complex - genetics
microsatellite
Microsatellite Repeats
Polymorphism, Genetic
susceptibility genes
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Summary:The Finnish population is genetically relatively homogeneous and has a narrow gene pool as a result of founder effect followed by rapid population growth. We here demonstrate that microsatellite markers are highly informative tools for major histocompatibility complex (MHC) analysis in this population. First, no variation in 12 MHC‐linked microsatellites could be observed in certain CYP21‐deficient chromosomes, which as a result of founder effect most likely derived from common ancestors. Second, amongst 131 Finnish chromosomes, some, but not all, apparently HLA‐identical chromosomes also carried identical microsatellites, suggesting that these loci could be applied for identification of haplotypes which have a relatively recent shared origins. Finally, when the microsatellites were studied between ethnically more distant individuals (Finnish vs. non‐Finnish), who were matched for the HLA alleles, much more differences were observed. This showed that the similarity in microsatellites was population specific. The microsatellite typing can therefore be informative in fine mapping MHC‐linked susceptibility genes and can help in matching bone marrow transplants in isolated populations. Linkage disequilibrium was found to be much higher in the MHC than in another region (5q31) of similar size, indicating that there may be particular mechanisms keeping the MHC haplotypes conserved.
ISSN:0001-2815
1399-0039
DOI:10.1034/j.1399-0039.2000.560106.x