The Kinetics of Leptin in Meigs' Syndrome

Objective. The aim of this study was to assess the kinetics and possible role of leptin in the pathophysiology of Meigs' syndrome. Methods. We report on a 62-year-old patient admitted for a large ovarian tumor, hydrothorax, and ascites. The patient underwent abdominal hysterectomy and bilateral...

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Bibliographic Details
Published in:Gynecologic oncology 2001-11, Vol.83 (2), p.316-318
Main Authors: Abramov, Yoram, Anteby, Shaoul O., Fatum, Mohammad, Fasouliotis, Sozos J., Barak, Vivian
Format: Article
Language:English
Subjects:
Ascitic Fluid - metabolism
Biological and medical sciences
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
leptin
Leptin - blood
Leptin - metabolism
Medical sciences
Meigs Syndrome - blood
Meigs Syndrome - metabolism
Meigs Syndrome - surgery
Meigs' syndrome
Middle Aged
Pleural Effusion - metabolism
Tumors
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Summary:Objective. The aim of this study was to assess the kinetics and possible role of leptin in the pathophysiology of Meigs' syndrome. Methods. We report on a 62-year-old patient admitted for a large ovarian tumor, hydrothorax, and ascites. The patient underwent abdominal hysterectomy and bilateral adnexectomy revealing a benign ovarian fibroma and no evidence of malignant cells in the pleural or peritoneal fluids. Analysis of serum, peritoneal, and pleural fluids from this patient was performed before, during, and after the operation. Results. Preoperatively, the patient had low levels of leptin in the serum, peritoneal, and pleural fluids. Serum levels increased after removal of the ovarian tumor along with the resolution of ascites and hydrothorax. Conclusion. Leptin levels inversely correlate to tumor burden, third space fluid accumulation, and clinical status in Meigs' syndrome. These findings suggest the involvement of leptin in the pathophysiology of this syndrome.
ISSN:0090-8258
1095-6859
DOI:10.1006/gyno.2001.6392