Risk Factors for Candida tropicalis Fungemia in Patients with Cancer

The risk factors for and presentation of Candida tropicalis fungemia, in comparison with those of Candida albicans, have been incompletely characterized. We compared 43 cases of C. tropicalis fungemia with 148 cases of C. albicans fungemia. In univariate analysis, patients with C. tropicalis fungemi...

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Bibliographic Details
Published in:Clinical infectious diseases 2001-11, Vol.33 (10), p.1676-1681
Main Authors: Kontoyiannis, Dimitrios P., Vaziri, Irfan, Hanna, Hend A., Boktour, Maha, Thornby, Jack, Hachem, Ray, Bodey, Gerald P., Raad, Issam I.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Antifungal Agents - therapeutic use
Antifungals
Biological and medical sciences
Blood
Candida - isolation & purification
Candida albicans - isolation & purification
Candida tropicalis
Candidemia
Candidiasis - drug therapy
Candidiasis - epidemiology
Candidiasis - microbiology
Child
Female
Fungemia
Fungemia - drug therapy
Fungemia - epidemiology
Fungemia - microbiology
Human mycoses
Humans
Infections
Infectious diseases
Intensive care units
Leukemia
Major Articles
Male
Medical sciences
Middle Aged
Mycoses
Mycotic sepsis
Neoplasms - complications
Neutropenia
Predisposing factors
Retrospective Studies
Risk Factors
Treatment Outcome
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Summary:The risk factors for and presentation of Candida tropicalis fungemia, in comparison with those of Candida albicans, have been incompletely characterized. We compared 43 cases of C. tropicalis fungemia with 148 cases of C. albicans fungemia. In univariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .0006), prolonged neutropenia (P = .03), and a positive blood culture for more days (P = .02). The 2 groups did not differ with regard to baseline Acute Physiology and Chronic Health Evaluation (APACHE) II score, frequency of catheter-associated fungemia, or response to antifungals. In multivariate analysis, patients with C. tropicalis fungemia were more likely to have leukemia (P = .02), previous neutropenia (P = .002), and a longer stay in the intensive care unit during the infectious episode (P = .01). Also, the response of the breakthrough C. tropicalis fungemia was lower (P = .05). In conclusion, the host determinants associated with susceptibility to C. tropicalis are leukemia and prolonged neutropenia.
ISSN:1058-4838
1537-6591
DOI:10.1086/323812