The effect of low-dose erythromycin on whole gastrointestinal transit time of preterm infants

The aim of the study was to determine the effect of a low oral dose of erythromycin on whole gastrointestinal transit time [WGTT]. Erythromycin [EM] [1.5 mg/kg, 6 hourly] or placebo was given first over 7 days in a double blind randomized crossover study of 21 preterm infants with feed intolerance....

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Bibliographic Details
Published in:Early human development 2001-12, Vol.65 (2), p.91-96
Main Authors: Costalos, C, Gavrili, V, Skouteri, V, Gounaris, A
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Dose-Response Relationship, Drug
Double-Blind Method
Erythromycin
Erythromycin - administration & dosage
Erythromycin - pharmacology
Feed intolerance
Female
Food Hypersensitivity - drug therapy
Gastrointestinal motility
Gastrointestinal Transit - drug effects
Gastrointestinal Transit - physiology
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Male
Medical sciences
Pharmacology. Drug treatments
Preterm infants
Treatment Outcome
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Summary:The aim of the study was to determine the effect of a low oral dose of erythromycin on whole gastrointestinal transit time [WGTT]. Erythromycin [EM] [1.5 mg/kg, 6 hourly] or placebo was given first over 7 days in a double blind randomized crossover study of 21 preterm infants with feed intolerance. Median [range] birth weight was 1420 [690, 2200] g and postconceptual age 32. 5 [20, 36.4] weeks. WGTT was assessed on day 3 of each treatment, by timing the transit of carmine red through the gut. Treatments were compared using Student's paired t test. Results: WGTT was significantly shorter following EM treatment as compared to placebo: mean [SD] 10.16 [4.6] h vs. 15. 9 [7.2] h, p
ISSN:0378-3782
1872-6232
DOI:10.1016/S0378-3782(01)00191-8