Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme

The focus of this review will be on the regulation of the multigenic invasion programme by activator protein-1 (AP-1). Investigation of AP-1-regulated gene expression in transformed cells can be used to identify the genes in the multigenic invasion programme and to validate them as targets for diagn...

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Bibliographic Details
Published in:European journal of cancer (1990) 2000-08, Vol.36 (13), p.1640-1648
Main Authors: Ozanne, B.W., McGarry, L., Spence, H.J., Johnston, I., Winnie, J., Meagher, L., Stapleton, G.
Format: Article
Language:English
Subjects:
AP-1
DNA, Complementary - genetics
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Invasion
Neoplasm Invasiveness - genetics
Neoplasm Proteins - genetics
Transcription Factor AP-1 - genetics
Up-Regulation
v- fos
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Summary:The focus of this review will be on the regulation of the multigenic invasion programme by activator protein-1 (AP-1). Investigation of AP-1-regulated gene expression in transformed cells can be used to identify the genes in the multigenic invasion programme and to validate them as targets for diagnosis or therapy.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(00)00175-1