Malignant granular cell tumour of the cervical sympathetic nerve trunk

Granular cell tumour is a rare neoplasm that can occur in various sites. This report describes a 48-year-old female with a malignant granular cell tumour originating from the cervical sympathetic nerve trunk, who presented with hyperaesthesia of the left shoulder. The tumour had a maximum diameter o...

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Bibliographic Details
Published in:Journal of laryngology and otology 2001-10, Vol.115 (10), p.833-835
Main Authors: Hyodo, Masamitsu, Sadamoto, Akiko, Murakami, Shingo
Format: Article
Language:English
Subjects:
(RF) Otorhinolaryngology
Autonomic Nervous System Diseases - diagnosis
Autonomic Nervous System Diseases - surgery
Biological and medical sciences
Cervical Vertebrae - pathology
Female
Granular Cell Tumor - diagnosis
Granular Cell Tumor - surgery
Granular Cell Tumour
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - surgery
Humans
Immunochemistry
Magnetic Resonance Imaging
Medical sciences
Middle Aged
Neurology
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Sympathetic Nervous System
Tomography, X-Ray Computed
Tumors
Tumors of the nervous system. Phacomatoses
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Summary:Granular cell tumour is a rare neoplasm that can occur in various sites. This report describes a 48-year-old female with a malignant granular cell tumour originating from the cervical sympathetic nerve trunk, who presented with hyperaesthesia of the left shoulder. The tumour had a maximum diameter of 86 mm and involved adjacent tissues directly. Histopathologically, it showed considerable variation in the size and shape of nuclei, with occasional mitosis and an abundant granular cytoplasm. Immunohistochemically, the tumour reacted positively for S-100 protein and neuron-specific enolase, indicating its neural origin. Following total local excision of the lesion, the patient has been well without recurrence.
ISSN:0022-2151
1748-5460
DOI:10.1258/0022215011909107