Clinical utility of selected disease activity markers in patients with systemic lupus erythematosus

The objective of this study was to assess the utility of measurement of thrombomodulin, antinucleosome antibodies, sVCAM-1, sICAM-1, neopterin, fas ligand, IL-10 and sIL-2R in patients with systemic lupus erythematosus (SLE) and to compare them with traditional markers of SLE activity (anti-dsDNA an...

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Bibliographic Details
Published in:Clinical rheumatology 2001-01, Vol.20 (5), p.337-344
Main Authors: Horák, P, Scudla, V, Hermanovó, Z, Pospisil, Z, Faltýnek, L, Budiková, M, Kusá, L
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Autoantibodies - analysis
Autoimmune diseases
Biomarkers - analysis
Cohort Studies
Cytokines - analysis
Enzyme-Linked Immunosorbent Assay
Female
Humans
Intercellular Adhesion Molecule-1 - analysis
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - diagnosis
Male
Middle Aged
Neopterin - analysis
Probability
Regression Analysis
Sampling Studies
Sensitivity and Specificity
Severity of Illness Index
Thrombomodulin - analysis
Vascular Cell Adhesion Molecule-1 - analysis
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Summary:The objective of this study was to assess the utility of measurement of thrombomodulin, antinucleosome antibodies, sVCAM-1, sICAM-1, neopterin, fas ligand, IL-10 and sIL-2R in patients with systemic lupus erythematosus (SLE) and to compare them with traditional markers of SLE activity (anti-dsDNA antibodies, C3, C4) and the ECLAM index of disease activity. The measurement was performed over a 6-month period at three consecutive time points after 3 months in each of the 52 patients with SLE. Anti-dsDNA antibodies, thrombomodulin, antinucleosome antibodies, sVCAM-1m sICAM-1, neopterin, fas ligand, IL-10 and sIL-2R were tested by ELISA technique, while C3, C4 components of complement were tested by nephelometry. Fas ligand and IL-10 did not correlate with the ECLAM index. The rest of the markers showed significant correlation with the disease activity index. Thrombomodulin and anti-dsDNA antibodies reflect in the best way the changing trend in disease activity. Antinucleosome antibodies seem to be a promising marker useful in early diagnosis. Soluble VCAM-1, sICAM-1, neopterin and sIL-2R are interesting molecules with a role in disease pathogenesis, but their practical utility is limited.
ISSN:0770-3198
1434-9949
DOI:10.1007/s100670170023