Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats

Effects of oral administration of the angiotensin II receptor antagonist (selective AT(1)-subtype) irbesartan on glucose tolerance and insulin action on skeletal-muscle glucose transport were assessed in the insulin-resistant obese Zucker rat. In the acute study, obese rats received either vehicle (...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-10, Vol.38 (4), p.884-890
Main Authors: HENRIKSEN, Erik J, JACOB, Stephan, KINNICK, Tyson R, TEACHEY, Mary K, KREKLER, Michael
Format: Article
Language:English
Subjects:
Angiotensin Receptor Antagonists
Animals
Antihypertensive agents
Area Under Curve
Biological and medical sciences
Biological Transport - drug effects
Biphenyl Compounds - pharmacology
Blood Glucose - drug effects
Blood Glucose - metabolism
Body Weight - drug effects
Cardiovascular system
Deoxyglucose - pharmacokinetics
Dose-Response Relationship, Drug
Fatty Acids, Nonesterified - metabolism
Female
Glucose Tolerance Test
Glucose Transporter Type 4
Heart - growth & development
Insulin - blood
Insulin - pharmacokinetics
Insulin - pharmacology
Insulin Resistance
Irbesartan
Medical sciences
Monosaccharide Transport Proteins - drug effects
Monosaccharide Transport Proteins - metabolism
Muscle Proteins
Muscle, Skeletal - drug effects
Muscle, Skeletal - metabolism
Obesity - metabolism
Organ Size - drug effects
Pharmacology. Drug treatments
Rats
Rats, Zucker
Tetrazoles - pharmacology
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Summary:Effects of oral administration of the angiotensin II receptor antagonist (selective AT(1)-subtype) irbesartan on glucose tolerance and insulin action on skeletal-muscle glucose transport were assessed in the insulin-resistant obese Zucker rat. In the acute study, obese rats received either vehicle (water) or irbesartan 1 hour before the experiment. Although irbesartan had no effect on glucose transport (2-deoxyglucose uptake) in the epitrochlearis muscle, which consists mainly of type IIb fibers, acute angiotensin II receptor antagonism led to a dose-dependent increase in insulin action in the predominantly type I soleus muscle. Irbesartan at 25 and 50 mg/kg induced significant increases (41% and 50%, respectively; P
ISSN:0194-911X
1524-4563
DOI:10.1161/hy1101.092970