Microdialysis assessment of shock wave lithotripsy-induced renal injury

Objectives. Shock wave lithotripsy (SWL) is the primary treatment modality for managing the majority of symptomatic renal calculi. However, the fundamental mechanisms for stone fragmentation and the resultant morphologic changes that occur are not fully understood. Furthermore, a thorough understand...

Full description

Saved in:
Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2000-09, Vol.56 (3), p.364-368
Main Authors: Brown, Spencer A, Munver, Ravi, Delvecchio, Fernando C, Kuo, Ramsay L, Zhong, Pei, Preminger, Glenn M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomarkers - analysis
Disease Models, Animal
Diseases of the urinary system
Extracellular Space
Female
Hemorrhage - diagnosis
Hemorrhage - etiology
Kidney - injuries
Kidney Diseases - diagnosis
Kidney Diseases - etiology
Lithotripsy - adverse effects
Medical sciences
Microdialysis - methods
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Swine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives. Shock wave lithotripsy (SWL) is the primary treatment modality for managing the majority of symptomatic renal calculi. However, the fundamental mechanisms for stone fragmentation and the resultant morphologic changes that occur are not fully understood. Furthermore, a thorough understanding of the complex biologic pathways involved in SWL-induced renal injury does not exist at present. To elucidate the biologic processes involved in tissue injury after SWL, an animal model was designed to mimic the pathogenesis of high-energy SWL in humans. Methods. Juvenile female swine were anesthetized, and a midline laparotomy incision was performed to expose the right kidney. Using an introducer apparatus, a microdialysis probe was placed into the renal parenchyma of the right kidney lower pole and a tunnel was generated to exit the distal ends of the inlet and outlet tubing outside the body. After a 72-hour postoperative recovery period, SWL was performed to the lower pole renal region of the kidney, as a microdialysis pump continuously infused dialysate through the inlet tubing. Microdialysis fluids were collected during SWL, and lipid peroxidation, as measured by conjugated diene concentrations, was monitored. Results. All microdialysis probes remained patent for a total of 2000 shock waves. A significant elevation in conjugated diene levels was observed in the SWL versus untreated kidneys after 1000 shock waves were administered ( P
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(00)00694-4