Immunopathogenesis of hepatitis B e antigen negative chronic hepatitis B infection

Hepatitis B e antigen (HBeAg) negative chronic hepatitis B represents currently the predominant form of chronic hepatitis due to the hepatitis B virus (HBV) in several parts of the world. In this review, recent data regarding the process of HBeAg negative HBV strain selection during the course of ch...

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Bibliographic Details
Published in:Antiviral research 2001-11, Vol.52 (2), p.91-98
Main Authors: Hadziyannis, Stephanos J, Vassilopoulos, Dimitrios
Format: Article
Language:English
Subjects:
Biological and medical sciences
Hepatitis B e Antigens - blood
Hepatitis B envelope antigen
Hepatitis B virus
Hepatitis B, Chronic - etiology
Hepatitis B, Chronic - immunology
Hepatitis B, Chronic - pathology
Hepatitis B, Chronic - virology
Human viral diseases
Humans
Infectious diseases
Medical sciences
Mutation
Viral diseases
Viral hepatitis
Virus Replication
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Summary:Hepatitis B e antigen (HBeAg) negative chronic hepatitis B represents currently the predominant form of chronic hepatitis due to the hepatitis B virus (HBV) in several parts of the world. In this review, recent data regarding the process of HBeAg negative HBV strain selection during the course of chronic HBV infection are presented and the potential virus and/or host-mediated mechanisms that lead to chronic liver necroinflammation, i.e. chronic hepatitis are outlined.
ISSN:0166-3542
1872-9096
DOI:10.1016/S0166-3542(01)00173-5