Identification of four additional myoinhibitory peptides (MIPs) from the ventral nerve cord of Manduca sexta

Four new myoinhibitory peptides were isolated and identified from the ventral nerve cord of adult Manduca sexta. The new peptides are related to two previously identified myoinhibitory peptides also isolated from adult M. sexta, Mas‐MIP I and Mas‐MIP II. The sequences of the new peptides are APEKWAA...

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Bibliographic Details
Published in:Archives of insect biochemistry and physiology 2001-11, Vol.48 (3), p.121-128
Main Authors: Blackburn, Michael B., Jaffe, Howard, Kochansky, Jan, Raina, Ashok K.
Format: Article
Language:English
Subjects:
allatostatin
Animals
Chemical Fractionation
Digestive System - drug effects
Electrophysiology
Insect Proteins - chemical synthesis
Insect Proteins - isolation & purification
Insect Proteins - physiology
Male
Manduca
Manduca sexta
Muscle Contraction - drug effects
Muscle Contraction - physiology
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
myoinhibiting peptide
myoinhibitory peptide
Neuromuscular Blocking Agents - chemical synthesis
Neuromuscular Blocking Agents - isolation & purification
Neuromuscular Blocking Agents - pharmacology
Neuropeptides - chemical synthesis
Neuropeptides - isolation & purification
Neuropeptides - physiology
Peripheral Nerves - chemistry
prothoracicostatin
Tissue Extracts - chemistry
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Summary:Four new myoinhibitory peptides were isolated and identified from the ventral nerve cord of adult Manduca sexta. The new peptides are related to two previously identified myoinhibitory peptides also isolated from adult M. sexta, Mas‐MIP I and Mas‐MIP II. The sequences of the new peptides are APEKWAAFHGSWamide (Mas‐MIP III), GWNDMSSAWamide (Mas‐MIP IV), GWQDMSSAWamide (Mas‐MIP V), and AWSALHGAWamide (Mas‐MIP VI). Mas‐MIPs III‐VI were found to inhibit spontaneous peristalsis of the adult M. sexta anterior hindgut (ileum) in vitro. Arch. Insect Biochem. Physiol. 48:121–128, 2001. Published 2001 Wiley‐Liss, Inc.
ISSN:0739-4462
1520-6327
DOI:10.1002/arch.1064