Secondary resistance among 554 isolates of Helicobacter pylori after failure of therapy

In a study to determine secondary resistance among Helicobacter pylori isolates, gastroenterologists from several German cities submitted over a 3-year period to centre A (Regensburg) or centre B (Freiburg) gastric biopsies from patients in whom one or more therapies to eradicate Helicobacter pylori...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2000-07, Vol.19 (7), p.538-541
Main Authors: HEEP, M, KIST, M, STROBEL, S, BECK, D, LEHN, N
Format: Article
Language:English
Subjects:
Amoxicillin - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Ciprofloxacin - pharmacology
Clarithromycin - pharmacology
Drug Resistance, Microbial
Failure
Gastroenterology
Germany
Helicobacter pylori
Helicobacter pylori - drug effects
Humans
Infections
Medical sciences
Metronidazole - pharmacology
Microbial Sensitivity Tests
Pharmacology. Drug treatments
secondary resistance
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Summary:In a study to determine secondary resistance among Helicobacter pylori isolates, gastroenterologists from several German cities submitted over a 3-year period to centre A (Regensburg) or centre B (Freiburg) gastric biopsies from patients in whom one or more therapies to eradicate Helicobacter pylori had failed. Rates of resistance among the collections of 302 (centre A) and 252 (centre B) isolates were, respectively, as follows: to metronidazole, 75% and 66%; to clarithromycin, 58% and 49%; to amoxicillin, 0%; to ciprofloxacin, 9%; to doxycycline, 0%; and to rifampin, 0%. Resistance to clarithromycin was associated with metronidazole resistance in 89% and 85% of the isolates in centre A and centre B, respectively.
ISSN:0934-9723
1435-4373
DOI:10.1007/s100960000288