Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation

Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the si...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular electrophysiology 2000-08, Vol.11 (8), p.913-921
Main Authors: ATHILL, CHARLES A., WU, TSU-JUEY, YASHIMA, MASAAKI, KIM, YOUNG-HOON, WEISS, JAMES N., HUANG, HSUN-LUN A., KARAGUEUZIAN, HRAYR S., CHEN, PENG-SHENG
Format: Article
Language:English
Subjects:
action potential duration
Action Potentials
Animals
Atrial Fibrillation - physiopathology
Cardiac Pacing, Artificial
Dogs
Electrophysiology
In Vitro Techniques
Membrane Potentials
Reaction Time
reentry
repolarization
wavefront
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the single cell action potential changes with the patterns of activation during AF. Methods and Results: We studied wavefront dynamics and single cell transmembrane potential (TMP) characteristics in 12 isolated perfused canine right atria. The endocardial surface was mapped using 477 bipolar electrodes while TMP was recorded with a standard glass microelectrode from an epicardial cell. AF was induced in the presence of acetylcholine. Successful simultaneous TMP recordings and activation maps were made during six episodes of AF and for a total of 141 activations. Large variations of TMP amplitude and duration were observed frequently; 34% of them have a low amplitude (
ISSN:1045-3873
1540-8167
DOI:10.1111/j.1540-8167.2000.tb00072.x