Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation

Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the si...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cardiovascular electrophysiology 2000-08, Vol.11 (8), p.913-921
Main Authors: ATHILL, CHARLES A., WU, TSU-JUEY, YASHIMA, MASAAKI, KIM, YOUNG-HOON, WEISS, JAMES N., HUANG, HSUN-LUN A., KARAGUEUZIAN, HRAYR S., CHEN, PENG-SHENG
Format: Article
Language:English
Subjects:
action potential duration
Action Potentials
Animals
Atrial Fibrillation - physiopathology
Cardiac Pacing, Artificial
Dogs
Electrophysiology
In Vitro Techniques
Membrane Potentials
Reaction Time
reentry
repolarization
wavefront
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c3513-f07eacee5f39a2881a8c38234d99ac125d070b071b020ca30451159e00c1caa53
container_end_page 921
container_issue 8
container_start_page 913
container_title Journal of cardiovascular electrophysiology
container_volume 11
creator ATHILL, CHARLES A.
WU, TSU-JUEY
YASHIMA, MASAAKI
KIM, YOUNG-HOON
WEISS, JAMES N.
HUANG, HSUN-LUN A.
KARAGUEUZIAN, HRAYR S.
CHEN, PENG-SHENG
description Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the single cell action potential changes with the patterns of activation during AF. Methods and Results: We studied wavefront dynamics and single cell transmembrane potential (TMP) characteristics in 12 isolated perfused canine right atria. The endocardial surface was mapped using 477 bipolar electrodes while TMP was recorded with a standard glass microelectrode from an epicardial cell. AF was induced in the presence of acetylcholine. Successful simultaneous TMP recordings and activation maps were made during six episodes of AF and for a total of 141 activations. Large variations of TMP amplitude and duration were observed frequently; 34% of them have a low amplitude (
doi_str_mv 10.1111/j.1540-8167.2000.tb00072.x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72221057</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72221057</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3513-f07eacee5f39a2881a8c38234d99ac125d070b071b020ca30451159e00c1caa53</originalsourceid><addsrcrecordid>eNqVkE1v3CAQhlHVqPnqX6isHnqzO8Cy2D1UijbZNNGqjfKhHBFmxy1bG6eAm91_Hyyvol7LgUGadx7gIeQjhYKm9XlTUDGDvKRzWTAAKGKddsmK7Rty9Np6m84wEzkvJT8kxyFsACifg3hHDilU80oKcUTwyjXtgM5g1jfZo_6Lje9dzM53TnfWhKx32b3XLnTY1alidtNHdNHqNlv80l6biN6GOEbPB2_dz-ws-rG7tLW3bauj7d0pOWh0G_D9vp6Qh-XF_eJbvvpxebU4W-WGC8rzBiRqgygaXmlWllSXhpeMz9ZVpQ1lYg0SapC0BgZG8_Q9SkWFAIYarQU_IZ8m7pPv_wwYoupsMJhe4bAfgpKMMQpCpuCXKWh8H4LHRj1522m_UxTUKFlt1GhSjSbVKFntJattGv6wv2WoO1z_MzpZTYGvU-DZtrj7D7S6XlxUlCdAPgGSWdy-ArT_reaSS6Eev18qVt3NblbLW3XHXwA-_Zxu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72221057</pqid></control><display><type>article</type><title>Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>ATHILL, CHARLES A. ; WU, TSU-JUEY ; YASHIMA, MASAAKI ; KIM, YOUNG-HOON ; WEISS, JAMES N. ; HUANG, HSUN-LUN A. ; KARAGUEUZIAN, HRAYR S. ; CHEN, PENG-SHENG</creator><creatorcontrib>ATHILL, CHARLES A. ; WU, TSU-JUEY ; YASHIMA, MASAAKI ; KIM, YOUNG-HOON ; WEISS, JAMES N. ; HUANG, HSUN-LUN A. ; KARAGUEUZIAN, HRAYR S. ; CHEN, PENG-SHENG</creatorcontrib><description>Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the single cell action potential changes with the patterns of activation during AF. Methods and Results: We studied wavefront dynamics and single cell transmembrane potential (TMP) characteristics in 12 isolated perfused canine right atria. The endocardial surface was mapped using 477 bipolar electrodes while TMP was recorded with a standard glass microelectrode from an epicardial cell. AF was induced in the presence of acetylcholine. Successful simultaneous TMP recordings and activation maps were made during six episodes of AF and for a total of 141 activations. Large variations of TMP amplitude and duration were observed frequently; 34% of them have a low amplitude (&lt;50% of the amplitude recorded during pacing). Low‐amplitude potentials were recorded when the impaled cell was (1) in an area of random reentry (67%, n = 36); (2) within 3.2 mm of the core of organized functional reentry (22%, n = 12); (3) in the middle of two merging wavefronts (9%, n = 5); and (4) at the point of spontaneous wavebreak (2%, n = 1). Conclusion: Large variations of TMP are observed frequently during in vitro AF. Low‐amplitude TMPs are associated with specific patterns of AF activation wavefronts.</description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/j.1540-8167.2000.tb00072.x</identifier><identifier>PMID: 10969755</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>action potential duration ; Action Potentials ; Animals ; Atrial Fibrillation - physiopathology ; Cardiac Pacing, Artificial ; Dogs ; Electrophysiology ; In Vitro Techniques ; Membrane Potentials ; Reaction Time ; reentry ; repolarization ; wavefront</subject><ispartof>Journal of cardiovascular electrophysiology, 2000-08, Vol.11 (8), p.913-921</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3513-f07eacee5f39a2881a8c38234d99ac125d070b071b020ca30451159e00c1caa53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27898,27899</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10969755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ATHILL, CHARLES A.</creatorcontrib><creatorcontrib>WU, TSU-JUEY</creatorcontrib><creatorcontrib>YASHIMA, MASAAKI</creatorcontrib><creatorcontrib>KIM, YOUNG-HOON</creatorcontrib><creatorcontrib>WEISS, JAMES N.</creatorcontrib><creatorcontrib>HUANG, HSUN-LUN A.</creatorcontrib><creatorcontrib>KARAGUEUZIAN, HRAYR S.</creatorcontrib><creatorcontrib>CHEN, PENG-SHENG</creatorcontrib><title>Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description>Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the single cell action potential changes with the patterns of activation during AF. Methods and Results: We studied wavefront dynamics and single cell transmembrane potential (TMP) characteristics in 12 isolated perfused canine right atria. The endocardial surface was mapped using 477 bipolar electrodes while TMP was recorded with a standard glass microelectrode from an epicardial cell. AF was induced in the presence of acetylcholine. Successful simultaneous TMP recordings and activation maps were made during six episodes of AF and for a total of 141 activations. Large variations of TMP amplitude and duration were observed frequently; 34% of them have a low amplitude (&lt;50% of the amplitude recorded during pacing). Low‐amplitude potentials were recorded when the impaled cell was (1) in an area of random reentry (67%, n = 36); (2) within 3.2 mm of the core of organized functional reentry (22%, n = 12); (3) in the middle of two merging wavefronts (9%, n = 5); and (4) at the point of spontaneous wavebreak (2%, n = 1). Conclusion: Large variations of TMP are observed frequently during in vitro AF. Low‐amplitude TMPs are associated with specific patterns of AF activation wavefronts.</description><subject>action potential duration</subject><subject>Action Potentials</subject><subject>Animals</subject><subject>Atrial Fibrillation - physiopathology</subject><subject>Cardiac Pacing, Artificial</subject><subject>Dogs</subject><subject>Electrophysiology</subject><subject>In Vitro Techniques</subject><subject>Membrane Potentials</subject><subject>Reaction Time</subject><subject>reentry</subject><subject>repolarization</subject><subject>wavefront</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqVkE1v3CAQhlHVqPnqX6isHnqzO8Cy2D1UijbZNNGqjfKhHBFmxy1bG6eAm91_Hyyvol7LgUGadx7gIeQjhYKm9XlTUDGDvKRzWTAAKGKddsmK7Rty9Np6m84wEzkvJT8kxyFsACifg3hHDilU80oKcUTwyjXtgM5g1jfZo_6Lje9dzM53TnfWhKx32b3XLnTY1alidtNHdNHqNlv80l6biN6GOEbPB2_dz-ws-rG7tLW3bauj7d0pOWh0G_D9vp6Qh-XF_eJbvvpxebU4W-WGC8rzBiRqgygaXmlWllSXhpeMz9ZVpQ1lYg0SapC0BgZG8_Q9SkWFAIYarQU_IZ8m7pPv_wwYoupsMJhe4bAfgpKMMQpCpuCXKWh8H4LHRj1522m_UxTUKFlt1GhSjSbVKFntJattGv6wv2WoO1z_MzpZTYGvU-DZtrj7D7S6XlxUlCdAPgGSWdy-ArT_reaSS6Eev18qVt3NblbLW3XHXwA-_Zxu</recordid><startdate>200008</startdate><enddate>200008</enddate><creator>ATHILL, CHARLES A.</creator><creator>WU, TSU-JUEY</creator><creator>YASHIMA, MASAAKI</creator><creator>KIM, YOUNG-HOON</creator><creator>WEISS, JAMES N.</creator><creator>HUANG, HSUN-LUN A.</creator><creator>KARAGUEUZIAN, HRAYR S.</creator><creator>CHEN, PENG-SHENG</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200008</creationdate><title>Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation</title><author>ATHILL, CHARLES A. ; WU, TSU-JUEY ; YASHIMA, MASAAKI ; KIM, YOUNG-HOON ; WEISS, JAMES N. ; HUANG, HSUN-LUN A. ; KARAGUEUZIAN, HRAYR S. ; CHEN, PENG-SHENG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3513-f07eacee5f39a2881a8c38234d99ac125d070b071b020ca30451159e00c1caa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>action potential duration</topic><topic>Action Potentials</topic><topic>Animals</topic><topic>Atrial Fibrillation - physiopathology</topic><topic>Cardiac Pacing, Artificial</topic><topic>Dogs</topic><topic>Electrophysiology</topic><topic>In Vitro Techniques</topic><topic>Membrane Potentials</topic><topic>Reaction Time</topic><topic>reentry</topic><topic>repolarization</topic><topic>wavefront</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ATHILL, CHARLES A.</creatorcontrib><creatorcontrib>WU, TSU-JUEY</creatorcontrib><creatorcontrib>YASHIMA, MASAAKI</creatorcontrib><creatorcontrib>KIM, YOUNG-HOON</creatorcontrib><creatorcontrib>WEISS, JAMES N.</creatorcontrib><creatorcontrib>HUANG, HSUN-LUN A.</creatorcontrib><creatorcontrib>KARAGUEUZIAN, HRAYR S.</creatorcontrib><creatorcontrib>CHEN, PENG-SHENG</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ATHILL, CHARLES A.</au><au>WU, TSU-JUEY</au><au>YASHIMA, MASAAKI</au><au>KIM, YOUNG-HOON</au><au>WEISS, JAMES N.</au><au>HUANG, HSUN-LUN A.</au><au>KARAGUEUZIAN, HRAYR S.</au><au>CHEN, PENG-SHENG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2000-08</date><risdate>2000</risdate><volume>11</volume><issue>8</issue><spage>913</spage><epage>921</epage><pages>913-921</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract>Transmembrane Potential Characteristics. Introduction: Although computerized mapping studies have demonstrated the presence of multiple wavelets during atrial fibrillation (AF) and that action potential amplitude and duration in AF vary significantly from beat to heat, no study has correlated the single cell action potential changes with the patterns of activation during AF. Methods and Results: We studied wavefront dynamics and single cell transmembrane potential (TMP) characteristics in 12 isolated perfused canine right atria. The endocardial surface was mapped using 477 bipolar electrodes while TMP was recorded with a standard glass microelectrode from an epicardial cell. AF was induced in the presence of acetylcholine. Successful simultaneous TMP recordings and activation maps were made during six episodes of AF and for a total of 141 activations. Large variations of TMP amplitude and duration were observed frequently; 34% of them have a low amplitude (&lt;50% of the amplitude recorded during pacing). Low‐amplitude potentials were recorded when the impaled cell was (1) in an area of random reentry (67%, n = 36); (2) within 3.2 mm of the core of organized functional reentry (22%, n = 12); (3) in the middle of two merging wavefronts (9%, n = 5); and (4) at the point of spontaneous wavebreak (2%, n = 1). Conclusion: Large variations of TMP are observed frequently during in vitro AF. Low‐amplitude TMPs are associated with specific patterns of AF activation wavefronts.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>10969755</pmid><doi>10.1111/j.1540-8167.2000.tb00072.x</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1045-3873
ispartof Journal of cardiovascular electrophysiology, 2000-08, Vol.11 (8), p.913-921
issn 1045-3873
1540-8167
language eng
recordid cdi_proquest_miscellaneous_72221057
source Wiley-Blackwell Read & Publish Collection
subjects action potential duration
Action Potentials
Animals
Atrial Fibrillation - physiopathology
Cardiac Pacing, Artificial
Dogs
Electrophysiology
In Vitro Techniques
Membrane Potentials
Reaction Time
reentry
repolarization
wavefront
title Influence of Wavefront Dynamics on Transmembrane Potential Characteristics During Atrial Fibrillation
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-25T23%3A21%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20Wavefront%20Dynamics%20on%20Transmembrane%20Potential%20Characteristics%20During%20Atrial%20Fibrillation&rft.jtitle=Journal%20of%20cardiovascular%20electrophysiology&rft.au=ATHILL,%20CHARLES%20A.&rft.date=2000-08&rft.volume=11&rft.issue=8&rft.spage=913&rft.epage=921&rft.pages=913-921&rft.issn=1045-3873&rft.eissn=1540-8167&rft_id=info:doi/10.1111/j.1540-8167.2000.tb00072.x&rft_dat=%3Cproquest_cross%3E72221057%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3513-f07eacee5f39a2881a8c38234d99ac125d070b071b020ca30451159e00c1caa53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=72221057&rft_id=info:pmid/10969755&rfr_iscdi=true