A water-cooled spherical niobium target for the production of [ 18F]fluoride

A new automated target system for the routine production of [ 18F]fluoride from 18O-enriched water has been constructed. It consists of a small spherical niobium target chamber mounted into a special holder, which provides rapid cooling by water flow around the sphere. The target is irradiated with...

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Bibliographic Details
Published in:Applied radiation and isotopes 2000-09, Vol.53 (3), p.449-453
Main Authors: Zeisler, S.K., Becker, D.W., Pavan, R.A., Moschel, R., Rühle, H.
Format: Article
Language:English
Subjects:
Fluorides - chemical synthesis
Fluorine Radioisotopes
Fluorodeoxyglucose F18 - chemical synthesis
Indicators and Reagents
Niobium
Oxygen Isotopes
Radiopharmaceuticals - chemical synthesis
Water
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Summary:A new automated target system for the routine production of [ 18F]fluoride from 18O-enriched water has been constructed. It consists of a small spherical niobium target chamber mounted into a special holder, which provides rapid cooling by water flow around the sphere. The target is irradiated with 21 MeV protons; the incident energy in the target chamber is 13 MeV. The system is operated without external over-pressure and has been tested for beam currents up to 50 μA. 95% of the theoretical yield of [ 18F]fluoride has been extracted and used for the synthesis of [ 18F]2-fluoro-2-deoxy- d-glucose.
ISSN:0969-8043
1872-9800
DOI:10.1016/S0969-8043(99)00254-7