Flow-mediated vasoactivity and circulating adhesion molecules in hypertriglyceridemia: Association with small, dense LDL cholesterol particles

Background Endothelial dysfunction is considered one of the earliest events in the process of atherosclerosis, and an impaired vasodilatory response has been reported in patients with dyslipidemias. However, the independent association between hypertriglyceridemia and endothelial dysfunction is cont...

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Published in:The American heart journal 2000-09, Vol.140 (3), p.521-526
Main Authors: Lupattelli, Graziana, Lombardini, Rita, Schillaci, Giuseppe, Ciuffetti, Giovanni, Marchesi, Simona, Siepi, Donatella, Mannarino, Elmo
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cell Adhesion Molecules - analysis
Cholesterol, LDL - analysis
Disorders of blood lipids. Hyperlipoproteinemia
Endothelium - physiology
Humans
Hypertriglyceridemia - pathology
Male
Medical sciences
Metabolic diseases
Particle Size
Vasodilation
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Summary:Background Endothelial dysfunction is considered one of the earliest events in the process of atherosclerosis, and an impaired vasodilatory response has been reported in patients with dyslipidemias. However, the independent association between hypertriglyceridemia and endothelial dysfunction is controversial, and the relation between endothelium-dependent vasodilation and circulating cell adhesion molecules as markers of endothelial dysfunction has not been fully determined. Methods Brachial artery flow mediated vasodilation (FMV) and the soluble forms of vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) were determined after overnight fasting in 16 men with hypertriglyceridemia (age 33 ± 6 years) and in 16 age-matched healthy men with normal triglycerides and cholesterol. Subjects who smoked and those with known cardiovascular disease, diabetes, hypertension, recent or active infections, or any other disease that could affect leukocyte activation were excluded from the study. Results Compared with normal subjects, subjects with hypertriglyceridemia showed a higher level of sVCAM-1 and sICAM-1 (both P
ISSN:0002-8703
1097-6744
DOI:10.1067/mhj.2000.108508