Linezolid Treatment of Prosthetic Hip Infections due to Methicillin-resistant Staphylococcus aureus (MRSA)

Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty. Complete removal of all foreign material is essential, however when prosthesis removal is not possible or contraindicated, suppressive antibiotic therapy with retention of the functioning hip arthroplas...

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Bibliographic Details
Published in:The Journal of infection 2001-08, Vol.43 (2), p.148-149
Main Authors: Bassetti, M., Di Biagio, A., Cenderello, G., Del Bono, V., Palermo, A., Cruciani, M., Bassetti, D.
Format: Article
Language:English
Subjects:
Acetamides - administration & dosage
Acetamides - therapeutic use
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - therapeutic use
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Arthroplasty, Replacement, Hip - adverse effects
Biological and medical sciences
Female
Humans
Linezolid
Medical sciences
Methicillin Resistance
Oxazolidinones - administration & dosage
Oxazolidinones - therapeutic use
Pharmacology. Drug treatments
Prosthesis-Related Infections - drug therapy
Staphylococcal Infections - drug therapy
Staphylococcus aureus - drug effects
Staphylococcus aureus - growth & development
Staphylococcus epidermidis - drug effects
Staphylococcus epidermidis - growth & development
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Summary:Prosthetic joint infection is an infrequent but serious complication of total joint arthroplasty. Complete removal of all foreign material is essential, however when prosthesis removal is not possible or contraindicated, suppressive antibiotic therapy with retention of the functioning hip arthroplasty may be considered. Linezolid, the first approved oxazolidinone, appears to be a promising new agent for the treatment of serious Gram-positive infections. We report two cases of Methicillin-resistant Staphylococcus aureus (MRSA) prosthetic hip infections successfully treated with a long course of linezolid. This observation suggest that linezolid is a promising drug for the treatment of prosthetic joint infections due to MRSA or other Gram-positive pathogens, particularly when other therapeutic approaches are not feasible or a long-term antibiotic therapy is required.
ISSN:0163-4453
1532-2742
DOI:10.1053/jinf.2001.0863