Differences among mechanisms of ribozyme-catalyzed reactions

The catalytic properties of ribozymes depend on the sophisticated structures of the respective ribozyme–substrate complexes. Although it has been suggested that ribozyme-mediated cleavage of RNA occurs via a rather strictly defined mechanism, recent findings have clearly demonstrated the diversity o...

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Bibliographic Details
Published in:Current Opinion in Biotechnology 2000-08, Vol.11 (4), p.354-362
Main Authors: Warashina, Masaki, Takagi, Yasuomi, Stec, Wojciech J, Taira, Kazunari
Format: Article
Language:English
Subjects:
Acids
Animals
Catalysis
Hammerhead
Hepatitis Delta Virus - genetics
Metal ion
Metals - metabolism
Reaction mechanism
RNA, Catalytic - chemistry
RNA, Catalytic - metabolism
Solvent isotope effect
Tetrahymena
Tetrahymena - genetics
Thio effect
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Summary:The catalytic properties of ribozymes depend on the sophisticated structures of the respective ribozyme–substrate complexes. Although it has been suggested that ribozyme-mediated cleavage of RNA occurs via a rather strictly defined mechanism, recent findings have clearly demonstrated the diversity of reaction mechanisms.
ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(00)00110-5