Contrasting influences of glucuronidation and O-methylation of epicatechin on hydrogen peroxide-induced cell death in neurons and fibroblasts

The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrastin...

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Bibliographic Details
Published in:Free radical biology & medicine 2001-11, Vol.31 (9), p.1139-1146
Main Authors: Spencer, J P, Schroeter, H, Crossthwaithe, A J, Kuhnle, G, Williams, R J, Rice-Evans, C
Format: Article
Language:English
Subjects:
Animals
Caspase 3
Caspases - drug effects
Caspases - metabolism
Catechin - analogs & derivatives
Catechin - metabolism
Catechin - pharmacology
Cell Death - drug effects
Cell Survival - drug effects
Cell Survival - physiology
Cells, Cultured
Cerebral Cortex - cytology
Dermis - cytology
epicatechin
Fibroblasts - drug effects
Fibroblasts - metabolism
Flavonoids - pharmacology
glucuronidation
Glucuronides - metabolism
Humans
Hydrogen Peroxide - antagonists & inhibitors
Hydrogen Peroxide - pharmacology
Methylation
Mice
Neurons - drug effects
Neurons - metabolism
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Summary:The purpose of this study was to examine the comparative mechanisms by which the dietary form of the flavonoid epicatechin and its predominant in vivo metabolite, epicatechin glucuronide, influence oxidative stress-induced cell death in fibroblasts and neurons. The results demonstrate the contrasting influences of in vivo glucuronidation and methylation on the bioactivity of epicatechin.
ISSN:0891-5849
DOI:10.1016/s0891-5849(01)00704-3