High Vegetable and Fruit Diet Intervention in Premenopausal Women with Cervical Intraepithelial Neoplasia

• Published in: Journal of the American Dietetic Association 2001-10, Vol.101 (10), p.1167-1174
• Main Authors: ROCK, CHERYL L, MOSKOWITZ, ANNA, HUIZAR, BRIAN, SAENZ, CHERYL C, CLARK, JENNIFER T, DALY, TRACY L, CHIN, HOMER, BEHLING, CYNTHIA, RUFFIN, MACK T
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Carotenoids - blood; Cervical Intraepithelial Neoplasia - blood; Cervical Intraepithelial Neoplasia - diet therapy; Cervix dysplasia; Diet; Female; Folic Acid - blood; Fruit; Fruit - chemistry; Fruits; Fruits (Food); Genital system. Mammary gland; Health aspects; Health Promotion; Homocysteine - blood; Humans; Medical sciences; Menopause; Middle Aged; Precancerous Conditions - blood; Precancerous Conditions - diet therapy; Premenopause; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Regression Analysis; Surveys and Questionnaires; Uterine Cervical Neoplasms - blood; Uterine Cervical Neoplasms - diet therapy; Vegetables; Vegetables - chemistry; Women
• ISSN: 0002-8223; 2212-2672; 1878-3570; 2212-2680
• DOI: 10.1016/S0002-8223(01)00286-3

Objective To examine whether diet intervention can promote increased vegetable and fruit intake, as reflected in increased plasma carotenoid and decreased plasma total homocysteine concentrations, in premenopausal women with cervical intraepithelial neoplasia, a precancerous condition. Design Randomized controlled diet intervention study. Subjects Fifty-three free-living premenopausal women who had been diagnosed with cervical intraepithelial neoplasia, were randomly assigned to an intervention (n=27) or a control (n=26) group. Intervention Individualized dietary counseling to increase vegetable and fruit intake. Main outcome measures Diet was assessed by food frequency questionnaire. Plasma carotenoids and total homocysteine were measured at enrollment and at 6 months follow up. Analysis Associations between baseline plasma concentrations of carotenoids and homocysteine and influencing factors were examined with multiple regression analysis. Repeated measures analysis of variance was used to test for group by time effects in these plasma concentrations. Plasma carotenoids at baseline and 6 months in the study groups, and differences in homocysteine concentrations from baseline to 6 months, were compared with independent sample t tests. Results Repeated measures analysis of variance showed significant group by time effects ( P