Day 5 versus day 3 embryo transfer: a controlled randomized trial

Blastocyst transfer has been suggested to improve implantation rate without affecting pregnancy rate. The aim of this study was to compare the pregnancy and implantation rates of day 3 and 5 transfers in a prospective randomized manner. Patients with four or more zygotes were randomly allocated on d...

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Bibliographic Details
Published in:Human reproduction (Oxford) 2000-09, Vol.15 (9), p.1947-1952
Main Authors: Coskun, Serdar, Hollanders, Johannes, Al-Hassan, Saad, Al-Sufyan, Hamad, Al-Mayman, Hend, Jaroudi, Kamal
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
blastocyst
Blastocyst - physiology
Culture Techniques
Embryo Implantation
embryo transfer
Embryo Transfer - methods
Embryo, Mammalian - physiology
Female
Fertilization in Vitro
Fundamental and applied biological sciences. Psychology
Humans
Mother. Fetoplacental unit. Mammary gland. Milk
Pregnancy
Pregnancy. Parturition. Lactation
Prospective Studies
sequential media
Sperm Injections, Intracytoplasmic
Time Factors
Vertebrates: reproduction
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Summary:Blastocyst transfer has been suggested to improve implantation rate without affecting pregnancy rate. The aim of this study was to compare the pregnancy and implantation rates of day 3 and 5 transfers in a prospective randomized manner. Patients with four or more zygotes were randomly allocated on day 1 to either day 3 or 5 transfers. Fertilization was achieved through regular IVF or intracytoplasmic sperm injection. Zygotes were kept in Medicult IVF medium for day 3 transfers and transferred into G1.2 and G2.2 on day 1 and 3 respectively for day 5 transfers. The morphologically best two or three embryos or blastocysts were chosen for transfer in both groups. Overall pregnancy rates per embryo transfer were the same (39%) in day 3 and 5 transfers. Implantation rates were 21 and 24% for day 3 and 5 transfers respectively. The pregnancy and implantation rates for day 5 transfers were significantly affected by the availability of at least one blastocyst to transfer and the number of zygotes. The number of good quality embryos on day 3 also significantly affected pregnancy and implantation rates on day 5 transfers. Multiple gestation rate, number of abortions and ongoing pregnancies were similar in both groups. In conclusion, day 3 and 5 transfer had similar pregnancy, implantation and twinning rates. Currently, day 5 transfers have no advantages over day 3 transfers.
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/15.9.1947