Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat

In order to improve the rat gene map and comparative mapping with the human and the mouse, we determined the chromosome localization of 54 rat genes. Most genes encode transcription factors or other regulatory proteins of cancer relevance. The human homologs of four genes were also assigned to their...

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Bibliographic Details
Published in:Mammalian genome 2000-09, Vol.11 (9), p.729-735
Main Authors: Szpirer, Claude, Van Vooren, Pascale, Rivière, Michèle, Scohy, Spohie, Collau, Geoffroy, Szpirer, Josiane
Format: Article
Language:English
Subjects:
Animals
Chromosome Mapping
chromosomes
diabetes
Genes
Genes - genetics
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Mice
Proteins
quantitative traits
radiation hybrid mapping
Rats
regulatory proteins
transcription factors
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Summary:In order to improve the rat gene map and comparative mapping with the human and the mouse, we determined the chromosome localization of 54 rat genes. Most genes encode transcription factors or other regulatory proteins of cancer relevance. The human homologs of four genes were also assigned to their respective chromosome. These data generated anchor points between the recently established radiation hybrid maps and the genetic and cytogenetic maps. They improve comparative mapping between the rat, the mouse, and the human gene maps, and in particular they disclose four new synteny groups conserved in the rat and the human. These new localizations should also be useful for the identification of genes involved in the control of quantitative traits such as cancer susceptibility or diabetes.
ISSN:0938-8990
1432-1777
DOI:10.1007/s003350010139