Renal Tubular Acidosis: A New Look at an Old Problem

Although the definition of renal tubular acidosis (RTA) is simple, understanding the physiologic basis underlying the various types of this clinical entity is much more difficult. The pathophysiology of this disorder is reviewed using the normal acid-base functions of the involved segments of the ne...

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Bibliographic Details
Published in:Clinical pediatrics 2001-10, Vol.40 (10), p.533-543
Main Authors: Roth, Karl S., Chan, James C. M.
Format: Article
Language:English
Subjects:
Acidosis
Acidosis, Renal Tubular - diagnosis
Acidosis, Renal Tubular - etiology
Acidosis, Renal Tubular - physiopathology
Adolescent
Algorithms
Biological and medical sciences
Child
Child, Preschool
Clinical trials
Growth Disorders - etiology
Humans
Hydrogen-Ion Concentration
Infant
Infant, Newborn
Kidney Tubules, Distal - physiology
Kidney Tubules, Proximal - physiology
Kidneys
Medical disorders
Medical sciences
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Pediatrics
Physiological aspects
Sodium-Bicarbonate Symporters - genetics
Sodium-Bicarbonate Symporters - metabolism
Tubulopathies
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Description
Summary:Although the definition of renal tubular acidosis (RTA) is simple, understanding the physiologic basis underlying the various types of this clinical entity is much more difficult. The pathophysiology of this disorder is reviewed using the normal acid-base functions of the involved segments of the nephron as a guide to understanding. Clinical and laboratory features of the subtypes of RTA are addressed, and diagnosis and treatment discussed. New developments in the knowledge and understanding of the associated growth disturbances, mineral metabolism, and molecular biology of RTA are also reviewed to provide the most current view of this relatively common pediatric entity.
ISSN:0009-9228
1938-2707
DOI:10.1177/000992280104001001