Myeloperoxidase-antineutrophil cytoplasmic antibody-associated sensorineural hearing loss

A 36-year-old female with hyperthyroidism that had been treated with propilthiouracil (PTU) complained of tinnitus and hearing loss in both ears. She was treated with steroid administration by an otolaryngologist; however, hearing continued to fluctuate when the steroids were tapered. Laboratory eva...

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Bibliographic Details
Published in:Auris, nasus, larynx nasus, larynx, 2001-05, Vol.28, p.S103-S106
Main Authors: Maguchi, Shiroh, Fukuda, Satoshi, Chida, Eiji, Terayama, Yoshihiko
Format: Article
Language:English
Subjects:
Adult
Antibodies, Antineutrophil Cytoplasmic - physiology
Antineutrophil cytoplasmic antibody
Autoimmune
Female
Hearing Loss, Sensorineural - immunology
Humans
Myeloperoxidase
Peroxidase - physiology
Sensorineural hearing loss
Vasculitis
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Summary:A 36-year-old female with hyperthyroidism that had been treated with propilthiouracil (PTU) complained of tinnitus and hearing loss in both ears. She was treated with steroid administration by an otolaryngologist; however, hearing continued to fluctuate when the steroids were tapered. Laboratory evaluation revealed a decreased complement level and elevated levels of immunoglobulin M (IgM) and myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA). With the withdrawal of PTU and high-dose methylprednisolone, she had excellent return of right-sided hearing. In recent years, there have been many reports about MPO-ANCA-associated small vessel vasculitis. Although any organ may be affected by this disease, there are no reports about MPO-ANCA-associated progressive hearing loss without any other organ involvement. The present case suggests the possibility that inner ear blood flow impairment due to ANCA-associated small vessel vasculitis induces the so-called autoimmune sensorineural hearing loss.
ISSN:0385-8146
1879-1476
DOI:10.1016/S0385-8146(00)00103-6