Correlation between carotid intima-media thickness and hematocrit and hemoglobin values in renal transplant recipients

Background: Cardiovascular diseases are the main causes of morbidity and mortality in kidney transplant recipients. Blood viscosity plays an important role in the development of arteriosclerosis in the general population. Since hematocrit (Ht) and hemoglobin (Hb) values are determinants of blood vis...

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Bibliographic Details
Published in:Clinical transplantation 2001-10, Vol.15 (5), p.349-353
Main Authors: Brzósko, Szymon, Łebkowska, Urszula, Małyszko, Jolanta, Hryszko, Tomasz, Pawlak, Krystyna, Myśliwiec, Michał
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carotid Arteries - diagnostic imaging
Case-Control Studies
Female
Fibrinogen - analysis
Hematocrit
hemoglobin
Hemoglobins - analysis
Homocysteine - blood
Humans
Immunoenzyme Techniques
intima-media thickness
Kidney Transplantation
Linear Models
Male
Medical sciences
Middle Aged
renal transplantation
Risk Factors
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
Tunica Intima - diagnostic imaging
Tunica Media - diagnostic imaging
Ultrasonography
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Summary:Background: Cardiovascular diseases are the main causes of morbidity and mortality in kidney transplant recipients. Blood viscosity plays an important role in the development of arteriosclerosis in the general population. Since hematocrit (Ht) and hemoglobin (Hb) values are determinants of blood viscosity, we decided to perform a study to check the possible relevance between these hemorheological factors and carotid intima–media thickness (IMT) in renal transplant recipients. 
Patients and methods: The study was performed on 33 clinically stable renal transplant recipients and 19 healthy persons. All subjects underwent ultrasonographic measurements of IMT. Analyzed clinical parameters included: age, sex, body mass index (BMI), mean arterial blood pressure (MAP), pulse pressure (PP) time from renal transplantation, and time on dialysis. The following biochemical parameters were assessed: Hb, Ht, fibrinogen (Fbg), and homocysteine (tHcy) concentrations (estimated by enzyme immunoassay). 
Results: The two analyzed groups did not differ in respect to age and BMI. Mean concentrations of Hb and Ht values were lower in the patients group. Mean carotid IMT, Fbg, tHcy, MAP, and PP were significantly higher in the renal transplant recipients group when compared to the control group. IMT was positively correlated with age (r=0.55; p=0.001), Hb (r=0.36; p=0.04), Ht (r=0.34; p
ISSN:0902-0063
1399-0012
DOI:10.1034/j.1399-0012.2001.150508.x