Delay of simple reaction time after levodopa intake

Background: Parkinsonian patients (PP) have deficits in the preparation and execution of movements. It is generally accepted that PP show delayed performance of simple reaction time (SRT) paradigms due to impaired response preprogramming. To date, no trial considered putative effects of dopaminergic...

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Bibliographic Details
Published in:Clinical neurophysiology 2001-11, Vol.112 (11), p.2133-2137
Main Authors: Müller, Thomas, Benz, Sabine, Börnke, Christian
Format: Article
Language:English
Subjects:
Adult
Aged
Antiparkinson Agents - administration & dosage
Antiparkinson Agents - therapeutic use
Behavior - drug effects
Benserazide - administration & dosage
Benserazide - therapeutic use
Biological and medical sciences
Cognition - drug effects
Dopamine Agents - administration & dosage
Dopamine Agents - therapeutic use
Drug Combinations
Drug toxicity and drugs side effects treatment
Female
Humans
Levodopa
Levodopa - administration & dosage
Levodopa - therapeutic use
Male
Medical sciences
Middle Aged
Movement - drug effects
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Parkinson Disease - psychology
Parkinson's disease
Pharmacology. Drug treatments
Psychiatric Status Rating Scales
Reaction Time - drug effects
Reference Values
Simple reaction time
Toxicity: nervous system and muscle
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Summary:Background: Parkinsonian patients (PP) have deficits in the preparation and execution of movements. It is generally accepted that PP show delayed performance of simple reaction time (SRT) paradigms due to impaired response preprogramming. To date, no trial considered putative effects of dopaminergic substitution on SRT performance in PP. Objectives: To determine short-term effects of acute levodopa intake and impact of long-term dopaminergic substitution on the results of a SRT task. Methods: We repeatedly performed a SRT paradigm in previously untreated- and treated PP, taken off medication for at least 12 h, before and after intake of levodopa/benserazide and in PP, who received placebo. Results: Reaction time significantly increased and movement time did not change after levodopa intake. Placebo application showed no effects. Conclusions: Levodopa delayed cognitive processing and/or behaviour. Sedative effects of levodopa and/or dopamine overflow in prefrontal regions with subsequent cholinergic dysfunction hypothetically caused this phenomenon.
ISSN:1388-2457
1872-8952
DOI:10.1016/S1388-2457(01)00653-8