The neutral theory in the genomic era

A number of tests have been developed to detect positive selection at the molecular level. These tests are based on DNA polymorphism within and divergence between species. Applications of these tests have revealed a large collection of genes that have evolved under positive selection and some genera...

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Bibliographic Details
Published in:Current Opinion in Genetics & Development 2001-12, Vol.11 (6), p.642-646
Main Authors: Fay, Justin C, Wu, Chung-I
Format: Article
Language:English
Subjects:
Animals
Drosophila - genetics
evolution
Evolution, Molecular
Gene Frequency
Genetic Variation - genetics
genome diversity
linkage disequilibrium
Polymorphism, Genetic
recombination
Selection, Genetic
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Summary:A number of tests have been developed to detect positive selection at the molecular level. These tests are based on DNA polymorphism within and divergence between species. Applications of these tests have revealed a large collection of genes that have evolved under positive selection and some general insights into adaptive evolution. Recently, these tests have been applied on a genomic scale and have provided estimates of the frequency of adaptive substitutions and a critical test of the neutral theory.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00247-1