Dexamethasone Inhibits CD4 T Cell Deletion Mediated by Macrophages from Human Immunodeficiency Virus–Infected Persons

Prednisolone slows the loss of CD4 T cells in individuals with human immunodeficiency virus (HIV) disease and inhibits antigen-induced apoptosis of recently HIV-infected CD4 cells in vitro. This study investigated whether dexamethasone inhibits the ability of macrophages to delete CD4 T cells via an...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2001-11, Vol.184 (10), p.1328-1330
Main Authors: Orlikowsky, Thorsten W., Wang, Z. Q., Dudhane, Anita, Dannecker, Günther E., Niethammer, Dietrich, Wormser, Gary P., Hoffmann, Michael K., Horowitz, Harold W.
Format: Article
Language:English
Subjects:
Adult
AIDS
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antibodies, Monoclonal - pharmacology
Antibody dependent cell cytotoxicity
Antibody-Dependent Cell Cytotoxicity - drug effects
Apoptosis
Biological and medical sciences
CD4 antigen
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD95 antigen
Concise Communications
Cultured cells
Cytotoxicity
dexamethasone
Dexamethasone - pharmacology
Dose-Response Relationship, Immunologic
fas Receptor - immunology
Glucocorticoids - pharmacology
glycoprotein gp120
HIV
HIV Envelope Protein gp120 - immunology
HIV Infections - immunology
HIV-1
Human immunodeficiency virus
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Lymphocytes
Macrophages
Macrophages - drug effects
Macrophages - immunology
Medical sciences
Monoclonal antibodies
Pharmacology. Drug treatments
T lymphocytes
Up-Regulation - drug effects
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Prednisolone slows the loss of CD4 T cells in individuals with human immunodeficiency virus (HIV) disease and inhibits antigen-induced apoptosis of recently HIV-infected CD4 cells in vitro. This study investigated whether dexamethasone inhibits the ability of macrophages to delete CD4 T cells via anti-CD4 antibody or immune-complexed HIV envelope protein gp120. Peripheral blood mononuclear cells from HIV-negative persons were incubated with CD4-reactive ch412 monoclonal antibody or with gp120/IgG immune complexes and resident macrophages, with and without dexamethasone. Dexamethasone inhibited CD4 cell deletion in a dose-dependent manner. The deletion of normal CD4 cells by macrophages from HIV-infected patients also was inhibited by dexamethasone. Furthermore, up-regulation of CD95 expression on T cells exposed to anti-CD4 and gp120/IgG, which predisposes T cells to CD95-mediated apoptosis, is inhibited by dexamethasone in a dose-dependent fashion. Dexamethasone inhibits the macrophage-mediated deletion of CD4 lymphocytes in HIV-infected persons
ISSN:0022-1899
1537-6613
DOI:10.1086/323997