Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer

Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an...

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Bibliographic Details
Published in:British journal of cancer 2000-10, Vol.83 (7), p.870-873
Main Authors: Grothey, A, Hashizume, R, Sahin, A A, McCrea, P D
Format: Article
Language:English
Subjects:
Actins - metabolism
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer Research
Carrier Proteins - biosynthesis
Carrier Proteins - genetics
Cell Movement - physiology
Drug Resistance
Epidemiology
Female
Flow Cytometry
Gene Expression Regulation, Neoplastic
Gynecology. Andrology. Obstetrics
Humans
Immunohistochemistry
Mammary gland diseases
Medical sciences
Microfilament Proteins - biosynthesis
Microfilament Proteins - genetics
Middle Aged
Molecular Medicine
Neoplasm Invasiveness
Oncology
Receptors, Estrogen - physiology
Receptors, Progesterone - physiology
short-communication
Tumors
Up-Regulation
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Description
Summary:Loss of hormone receptor (HR) status in breast carcinomas is associated with increased tumour cell motility and invasiveness. In an immunohistological study of 58 primary breast cancers, oestrogen (ER) and progesterone (PR) receptor levels were inversely correlated with the expression of fascin, an actin-bundling protein associated with cell motility ( P < 0.0001 and P = 0.0019, respectively). In addition, fascin was preferentially expressed in non-diploid tumours ( P = 0.03). In summary, the upregulation of fascin in HR-negative breast cancers may contribute to their more aggressive behaviour. © 2000 Cancer Research Campaign
ISSN:0007-0920
1532-1827
DOI:10.1054/bjoc.2000.1395