Longitudinal relationship among growth, nutritional status, and pulmonary function in children with cystic fibrosis: Analysis of the Cystic Fibrosis Foundation National CF Patient Registry

Objective: To determine prospectively the relationship among growth, nutritional status, and pulmonary function over a 4-year period in a large cohort of children with cystic fibrosis (CF). Study design: CF Foundation National CF Patient Registry data collected from 1991 to 1995 for 968 children (50...

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Bibliographic Details
Published in:The Journal of pediatrics 2000-09, Vol.137 (3), p.374-380
Main Authors: Zemel, Babette S., Jawad, Abbas F., FitzSimmons, Stacey, Stallings, Virginia A.
Format: Article
Language:English
Subjects:
Body Height
Body Weight
Child
Cystic Fibrosis - complications
Cystic Fibrosis - physiopathology
Disease Progression
Exocrine Pancreatic Insufficiency - complications
Female
Forced Expiratory Volume
Growth
Hospitalization
Humans
Longitudinal Studies
Lung - physiopathology
Male
Nutritional Status
Prospective Studies
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Summary:Objective: To determine prospectively the relationship among growth, nutritional status, and pulmonary function over a 4-year period in a large cohort of children with cystic fibrosis (CF). Study design: CF Foundation National CF Patient Registry data collected from 1991 to 1995 for 968 children (507 male) aged 5 to 8 years with pancreatic insufficiency and forced expiratory volume in 1 second within 60% to 140% of predicted values (FEV1%) were analyzed longitudinally. Variables hypothesized to affect FEV1% included age, sex, z scores for height, weight, percent of height-appropriate body weight, and annual number of days hospitalized. Results: The significant decline in FEV1% was curvilinear and dependent on baseline FEV1%; children with initial FEV1% ≥90 declined 2.6 U/y more than those with initial FEV1%
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2000.107891