Transglutaminase antibodies in children with a genetic risk for celiac disease

Objectives: The transglutaminase (TG) antibody test is accurate in identifying celiac disease in symptomatic children. We sought to determine the positive predictive value of this test in asymptomatic children at genetic risk for celiac disease. Study design: Asymptomatic children with a genetic ris...

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Bibliographic Details
Published in:The Journal of pediatrics 2000-09, Vol.137 (3), p.356-360
Main Authors: Hoffenberg, Edward J., Bao, Fei, Eisenbarth, George S., Uhlhorn, Cynthia, Haas, Joel E., Sokol, Ronald J., Rewers, Marian
Format: Article
Language:English
Subjects:
Adolescent
Autoantibodies - analysis
Biological and medical sciences
Celiac Disease - diagnosis
Celiac Disease - enzymology
Celiac Disease - genetics
Child
Child, Preschool
Digestive system
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genetic Predisposition to Disease
Humans
Intestine, Small - enzymology
Intestine, Small - immunology
Intestine, Small - pathology
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Other diseases. Semiology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Predictive Value of Tests
Radioimmunoassay
Statistics, Nonparametric
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transglutaminases - immunology
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Summary:Objectives: The transglutaminase (TG) antibody test is accurate in identifying celiac disease in symptomatic children. We sought to determine the positive predictive value of this test in asymptomatic children at genetic risk for celiac disease. Study design: Asymptomatic children with a genetic risk for celiac disease were studied to investigate the relationships between TG antibody titer, small bowel histology, growth, and clinical features. Small bowel biopsy histology was graded by using the system of Marsh. Results: Of 30 children with a positive TG antibody test result, 21 (70%) had definite (Marsh score 2 or 3) and 4 (13%) had possible (Marsh score 1) biopsy evidence of celiac disease. TG antibody titer correlated with Marsh score (r = 0.569, P
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2000.107582