Adaptive hitchhiking effects on genome variability

The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping genome-wide patterns of variability and molecular evolution. Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footp...

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Bibliographic Details
Published in:Current Opinion in Genetics & Development 2001-12, Vol.11 (6), p.635-641
Main Author: Andolfatto, Peter
Format: Article
Language:English
Subjects:
adaptation
Adaptation, Biological - genetics
Animals
background selection
Chromosomes - genetics
deleterious mutations
demography
Drosophila
Evolution, Molecular
Gene Frequency
Genetic Linkage
Genetic Variation
human
Humans
linkage
Mutation
polymorphism
Polymorphism, Genetic - genetics
Probability
Recombination, Genetic - genetics
Selection, Genetic
selective sweep
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Summary:The continuing deluge of nucleotide polymorphism data is providing insights into the role of adaptation in shaping genome-wide patterns of variability and molecular evolution. Population genetic models in which linkage and selection interact (i.e. hitchhiking) predict that selection can leave ‘footprints’ in closely linked genomic regions. New analytical approaches show promise for distinguishing the signature of adaptation from that of several non-adaptive alternatives. Accounting for the effects of population structure and history poses a challenge for future investigations.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(00)00246-X