BIOLOGICAL VARIATION OF INTERLEUKIN 6 (IL-6) AND SOLUBLE INTERLEUKIN 2 RECEPTOR (sIL2R) IN SERUM OF HEALTHY INDIVIDUALS

The biological variation of interleukin 6 (IL-6) and soluble interleukin 2 receptor (sIL2R), measured by automated enzyme immunoassay, in fifteen subjects studied at regular monthly intervals over a period of 6 consecutive months was measured. The mean and standard deviation (SD), within-subject CV,...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2000-09, Vol.12 (9), p.1423-1425
Main Authors: Cava, F, González, C, Pascual, M.J, Navajo, J.A, González-Buitrago, J.M
Format: Article
Language:English
Subjects:
Adult
biological variation/critical differences/index of individuality/interleukin 6soluble interleukin 2 receptor
Female
Humans
Immunoenzyme Techniques
Interleukin-6 - blood
Male
Middle Aged
Models, Statistical
Receptors, Interleukin-2 - blood
Reference Values
Time Factors
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Summary:The biological variation of interleukin 6 (IL-6) and soluble interleukin 2 receptor (sIL2R), measured by automated enzyme immunoassay, in fifteen subjects studied at regular monthly intervals over a period of 6 consecutive months was measured. The mean and standard deviation (SD), within-subject CV, between-subject CV, individuality index (II) and reliability coefficient (R) were as follow: for sIL2R 571 (231) U/ml, 5.84%, 38.81%, 0.21 and 0.93; and for IL-6 1.43 (0.9) pg/ml, 48.48%, 39.38%, 1.44, and 0.37. The data indicate a relatively high between-subject CV, quite similar in both cases, and a within-subject CV much higher for IL-6 than for sIL2R. Thus, reference values can be used for diagnosis for IL6 (high II), while not for sIL2R (low II). However, the low R for IL-6 implies that more than one measurement are needed. sIL2R has a very high R and a relatively small critical differences, a circumstance appropriate for follow-up.
ISSN:1043-4666
1096-0023
DOI:10.1006/cyto.2000.0714