Lymphocyte peripheral benzodiazepine receptor mRNA decreases in obsessive-compulsive disorder

The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD pa...

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Bibliographic Details
Published in:European neuropsychopharmacology 2000-09, Vol.10 (5), p.337-340
Main Authors: Rocca, Paola, Beoni, Anna Maria, Eva, Carola, Ferrero, Patrizia, Maina, Giuseppe, Bogetto, Filippo, Ravizza, Luigi
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anxiety disorders
Clinical subtypes
Female
Humans
Isoquinolines - pharmacokinetics
Lymphocytes - metabolism
Male
Obsessive-compulsive disorder
Obsessive-Compulsive Disorder - genetics
Obsessive-Compulsive Disorder - immunology
Obsessive-Compulsive Disorder - physiopathology
Peripheral benzodiazepine receptor mRNA
Receptors, GABA-A - blood
Receptors, GABA-A - genetics
RNA, Messenger - blood
Transcription, Genetic
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Summary:The relative content of peripheral benzodiazepine receptor (pBR) mRNA was examined by reverse transcriptase-polymerase chain reaction in lymphocytes of obsessive-compulsive disorder (OCD) patients, according to their clinical course of illness. pBR mRNA significantly decreased only in chronic OCD patients ( n=8) as compared to controls ( n=10), whereas no significant changes were observed in episodic OCD patients ( n=7). We suggest that modulation of pBR gene expression might delineate a clinical heterogeneity in OCD.
ISSN:0924-977X
1873-7862
DOI:10.1016/S0924-977X(00)00091-2