Hypoxia: the tumor's gateway to progression along the angiogenic pathway

Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible fact...

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Bibliographic Details
Published in:Trends in cell biology 2001-11, Vol.11 (11), p.S32-S36
Main Authors: Brahimi-Horn, C, Berra, E, Pouysségur, J
Format: Article
Language:English
Subjects:
Animals
Cell Hypoxia
Genetic Therapy
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
Mixed Function Oxygenases - metabolism
Neoplasms - pathology
Neoplasms - physiopathology
Neoplasms - therapy
Neovascularization, Pathologic
Oxygenases - metabolism
Signal Transduction - physiology
Transcription Factors - chemistry
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that promote vascularization and thereby enhance tumor growth and metastasis. Recent major advances have provided insight into the role hypoxia plays in cancer biology. The domain structure of the hypoxia-inducible factor 1alpha (HIF-1alpha) has been elucidated, as has the mechanism by which stabilization of HIF-1alpha leads to initiation of the transcription of target genes involved in growth of blood vessels.
ISSN:0962-8924
DOI:10.1016/s0962-8924(01)02126-2