The Role of High-Density Lipoproteins in Oxidation and Inflammation

High-density lipoproteins (HDL) in the basal state are anti-inflammatory, capable of destroying oxidized lipids that generate an inflammatory response. However, HDL during acute inflammation are altered and become pro-inflammatory. This “chameleon-like” nature of HDL is considered to be due to the c...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cardiovascular medicine 2001-04, Vol.11 (3), p.155-161
Main Authors: Van Lenten, Brian J, Navab, Mohamad, Shih, Diana, Fogelman, Alan M, Lusis, Aldons J
Format: Article
Language:English
Subjects:
Animals
Humans
Inflammation - metabolism
Inflammation Mediators - physiology
Lipid Peroxidation - physiology
Lipoproteins, HDL - physiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:High-density lipoproteins (HDL) in the basal state are anti-inflammatory, capable of destroying oxidized lipids that generate an inflammatory response. However, HDL during acute inflammation are altered and become pro-inflammatory. This “chameleon-like” nature of HDL is considered to be due to the complex composition of HDL. The data reviewed here demonstrate the key role of HDL in modulating inflammation and its implications for atherogenesis.
ISSN:1050-1738
1873-2615
DOI:10.1016/S1050-1738(01)00095-0