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fMRI of visual system activation in the conscious rabbit
A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without...
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| Published in: | Magnetic resonance in medicine 2000-09, Vol.44 (3), p.474-478 |
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| container_end_page | 478 |
| container_issue | 3 |
| container_start_page | 474 |
| container_title | Magnetic resonance in medicine |
| container_volume | 44 |
| creator | Wyrwicz, Alice M. Chen, Nan-kuei Li, Limin Weiss, Craig Disterhoft, John F. |
| description | A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. The conscious animal model can be applied to functional studies of sensory systems, learning and memory, and drug‐induced cerebral activation. Magn Reson Med 44:474–478, 2000. © 2000 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/1522-2594(200009)44:3<474::AID-MRM19>3.0.CO;2-I |
| format | article |
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Nmr spectrometry ; Reproducibility of Results ; Restraint, Physical ; visual cortex ; Visual Cortex - anatomy & histology ; Visual Cortex - physiology ; Visual Pathways - physiology ; Visual Perception - physiology ; Wakefulness - physiology</subject><ispartof>Magnetic resonance in medicine, 2000-09, Vol.44 (3), p.474-478</ispartof><rights>Copyright © 2000 Wiley‐Liss, Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4929-afe43b9bdebbe2726fc017e282474e0ec7b14ecf2d039db5add16239390133fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1528131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10975901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wyrwicz, Alice M.</creatorcontrib><creatorcontrib>Chen, Nan-kuei</creatorcontrib><creatorcontrib>Li, Limin</creatorcontrib><creatorcontrib>Weiss, Craig</creatorcontrib><creatorcontrib>Disterhoft, John F.</creatorcontrib><title>fMRI of visual system activation in the conscious rabbit</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. The conscious animal model can be applied to functional studies of sensory systems, learning and memory, and drug‐induced cerebral activation. Magn Reson Med 44:474–478, 2000. © 2000 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BOLD</subject><subject>Brain Mapping</subject><subject>conscious animal model</subject><subject>fMRI</subject><subject>functional activations</subject><subject>Geniculate Bodies - anatomy & histology</subject><subject>Geniculate Bodies - physiology</subject><subject>Image Enhancement</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Photic Stimulation</subject><subject>Rabbits</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Reproducibility of Results</subject><subject>Restraint, Physical</subject><subject>visual cortex</subject><subject>Visual Cortex - anatomy & histology</subject><subject>Visual Cortex - physiology</subject><subject>Visual Pathways - physiology</subject><subject>Visual Perception - physiology</subject><subject>Wakefulness - physiology</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqVkU9v0zAYh60JtJWxr4ByQAgOKf6XuC4IacrYiNRS0Q1tt1e2YwuzNBlxOui3x1mqwYELvlh69fjnnx8jJAieEozpW5JRmtJM8tcUxyXfcD5n77ng8_lpeZYu10siP7ApnhardzQtD9Dk8cQTNMGC45QRyY_QsxC-DwFS8EN0RLAUmcRkgmZuuS6T1iX3PmxVnYRd6O0mUab396r3bZP4Jum_2cS0TTC-3YakU1r7_jl66lQd7Ml-P0Zfzz9eFZ_SxeqiLE4XqeGSylQ5y5mWurJaWypo7gwmwtIZjY-w2BqhCbfG0QozWelMVRXJKZMstmPMaXaMXo25d137Y2tDDxsfjK1r1djYBgSlnOQcR3A1gqZrQ-isg7vOb1S3A4JhkAmDGhjUwCgTOAcGsQdAlAkPMuMAQ7ECCmVMfLG_eqs3tvorb7QXgZd7QAWjatepxvjwh8vojLAB-zJiP31td_9R61-txkHMTMdMH__r12Om6m4hF0xkcP35AtaL_Ly4vGFwxn4DgSanbQ</recordid><startdate>200009</startdate><enddate>200009</enddate><creator>Wyrwicz, Alice M.</creator><creator>Chen, Nan-kuei</creator><creator>Li, Limin</creator><creator>Weiss, Craig</creator><creator>Disterhoft, John F.</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200009</creationdate><title>fMRI of visual system activation in the conscious rabbit</title><author>Wyrwicz, Alice M. ; Chen, Nan-kuei ; Li, Limin ; Weiss, Craig ; Disterhoft, John F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4929-afe43b9bdebbe2726fc017e282474e0ec7b14ecf2d039db5add16239390133fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BOLD</topic><topic>Brain Mapping</topic><topic>conscious animal model</topic><topic>fMRI</topic><topic>functional activations</topic><topic>Geniculate Bodies - anatomy & histology</topic><topic>Geniculate Bodies - physiology</topic><topic>Image Enhancement</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Photic Stimulation</topic><topic>Rabbits</topic><topic>Radiodiagnosis. 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Nmr spectrometry</topic><topic>Reproducibility of Results</topic><topic>Restraint, Physical</topic><topic>visual cortex</topic><topic>Visual Cortex - anatomy & histology</topic><topic>Visual Cortex - physiology</topic><topic>Visual Pathways - physiology</topic><topic>Visual Perception - physiology</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wyrwicz, Alice M.</creatorcontrib><creatorcontrib>Chen, Nan-kuei</creatorcontrib><creatorcontrib>Li, Limin</creatorcontrib><creatorcontrib>Weiss, Craig</creatorcontrib><creatorcontrib>Disterhoft, John F.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wyrwicz, Alice M.</au><au>Chen, Nan-kuei</au><au>Li, Limin</au><au>Weiss, Craig</au><au>Disterhoft, John F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>fMRI of visual system activation in the conscious rabbit</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2000-09</date><risdate>2000</risdate><volume>44</volume><issue>3</issue><spage>474</spage><epage>478</epage><pages>474-478</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>A conscious rabbit preparation developed for fMRI, and the results from visual stimulation studies at a 4.7T magnetic field are described. The rabbit is ideal for these experiments because of its natural tolerance for restraint. High spatial and temporal resolution magnetic resonance images, without movement artifacts, were obtained during long periods of restraint. Functional activation in primary visual cortex and lateral geniculate nucleus (LGN) were reproducibly observed in response to light stimulus. In comparison to existing anesthetized animal models, a functional response free of the anesthetic modulation can be recorded with the new approach. 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| ispartof | Magnetic resonance in medicine, 2000-09, Vol.44 (3), p.474-478 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Animals Biological and medical sciences BOLD Brain Mapping conscious animal model fMRI functional activations Geniculate Bodies - anatomy & histology Geniculate Bodies - physiology Image Enhancement Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Nervous system Photic Stimulation Rabbits Radiodiagnosis. Nmr imagery. Nmr spectrometry Reproducibility of Results Restraint, Physical visual cortex Visual Cortex - anatomy & histology Visual Cortex - physiology Visual Pathways - physiology Visual Perception - physiology Wakefulness - physiology |
| title | fMRI of visual system activation in the conscious rabbit |
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